Oxygen Delivery and Utilization in Hypoxic Dogs Made Acidemic and Alkalemic
A long-standing point of discussion in studies of oxygen transport and delivery during hypoxia has been the relative importance of the driving pressure or PO2 and the quantity available at the tissue or volume of oxygen delivered per unit time. Because the position of the oxyhemoglobin dissociation curve governs to some extent the ease with which oxygen is loaded at the lung and its driving pressure when unloaded at the tissue, acidemia and alkalemia imposed during hypoxia should affect the quality and quantity of oxygen delivery by their effect upon the position of the dissociation curve, the Bohr effect. To judge whether either condition offers an advantage at a similar level of hypoxia, hypoxic survival time and oxygen uptake were compared to usual parameters of oxygen availability and transport in anesthetized and paralyzed dogs ventilated on an oxygen mixture too low to support the control level of oxygen uptake.
KeywordsOxygen Uptake Oxygen Delivery Oxygen Availability Cobalt Chloride Driving Pressure
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