Oxygen Delivery and Utilization in Hypoxic Dogs Made Acidemic and Alkalemic

  • Stephen M. Cain
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 75)


A long-standing point of discussion in studies of oxygen transport and delivery during hypoxia has been the relative importance of the driving pressure or PO2 and the quantity available at the tissue or volume of oxygen delivered per unit time. Because the position of the oxyhemoglobin dissociation curve governs to some extent the ease with which oxygen is loaded at the lung and its driving pressure when unloaded at the tissue, acidemia and alkalemia imposed during hypoxia should affect the quality and quantity of oxygen delivery by their effect upon the position of the dissociation curve, the Bohr effect. To judge whether either condition offers an advantage at a similar level of hypoxia, hypoxic survival time and oxygen uptake were compared to usual parameters of oxygen availability and transport in anesthetized and paralyzed dogs ventilated on an oxygen mixture too low to support the control level of oxygen uptake.


Oxygen Uptake Oxygen Delivery Oxygen Availability Cobalt Chloride Driving Pressure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Cain, S.M. Appearance of excess lactate in anesthetized dogs during anemic and hypoxic hypoxia. Am. J. Physiol. 209:604–610, 1965.PubMedGoogle Scholar
  2. 2.
    Cain, S.M. Diminution of lactate rise during hypoxia by PCO2 and β-adrenergic blockade. Am. J. Physiol. 271:110–116, 1969.Google Scholar
  3. 3.
    Cain, S.M. Survival time of hypoxic dogs given epinephrine or propranolol. Am. J. Physiol. 225:1405–1410, 1973.PubMedGoogle Scholar
  4. 4.
    Cain, S.M. Oxygen delivery and utilization in dogs with a sublethal dose of cobalt chloride. J. Appl. Physiol. 38: 20–25, 1975.PubMedGoogle Scholar
  5. 5.
    Krogh, A. The number and distributions of capillaries in muscles with calculations of the oxygen pressure head necessary for supplying the tissue. J. Physiol. (Lond.) 52:405–415, 1919.Google Scholar
  6. 6.
    Shepherd, A.P., H.J. Granger, E.E. Smith, and A.C. Guyton. Local control of tissue oxygen delivery and its contribution to the regulation of cardiac output. Am. J. Physiol. 225: 747–755, 1973.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Stephen M. Cain
    • 1
  1. 1.University of Alabama Medical CenterBirminghamUSA

Personalised recommendations