Pulmonary Tissue Oxygen Requirement
Earlier studies in an animal model of granulomatous lung disease demonstrated that at normal alveolar oxygen pressure the diseased lung apparently consumed oxygen but did not produce lactate, whereas under hypoxia oxygen consumption diminished and lactate production developed (1–3). Although oxygen uptake decreased when the alveolar oxygen pressure fell below 100 mm Hg, no conclusion was possible regarding the exact tissue oxygen pressure at which this response to hypoxia was manifest. The present studies in lung slices were designed to determine more precisely the oxygen requirement for pulmonary tissue respiration.
KeywordsOxygen Consumption Oxygen Uptake Oxygen Pressure Sodium Lauryl Sulfate Pulmonary Tissue
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