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Effect of Vasopressors and Hemorrhage on Intrarenal Oxygenation

  • Rex Baker
  • Anthony V. Beran
  • Jose Strauss
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 75)

Abstract

Hemorrhagic hypotension has been reported to be accompanied by liberation of catecholamines (1) and angiotensin (2). Aukland observed parallel blood flow decreases in cortex and outer medulla during hemorrhage and the injection of various vasopressor agents (3). From these data he suggested that vasopressors may be largely responsible for the increased renal vascular resistance of hemorrhagic hypotension. On the other hand, Rector et al. (4) observed intracortical blood flow redistribution during hemorrhage, but none during norepinephrine or angiotensin infusion. This suggested that the observed hemorrhagic intrarenal redistribution was due to factors other than humoral release of either norepinephrine or angiotensin. Grandchamp et al. (5) have suggested that the simultaneous action of both norepinephrine and local angiotensin are needed to produce the intrarenal blood flow redistribution of hemorrhagic hypotension.

Keywords

Hemorrhagic Shock Renin Secretion Renal Vascular Resistance Vasopressor Agent Renal Oxygenation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Rex Baker
    • 1
    • 2
  • Anthony V. Beran
    • 1
    • 2
  • Jose Strauss
    • 1
    • 2
  1. 1.Departments of PediatricsUniversity of Miami School of MedicineMiamiUSA
  2. 2.California College of MedicineU.C. IrvineIrvineUSA

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