Effect of Vasopressors and Hemorrhage on Intrarenal Oxygenation

  • Rex Baker
  • Anthony V. Beran
  • Jose Strauss
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 75)


Hemorrhagic hypotension has been reported to be accompanied by liberation of catecholamines (1) and angiotensin (2). Aukland observed parallel blood flow decreases in cortex and outer medulla during hemorrhage and the injection of various vasopressor agents (3). From these data he suggested that vasopressors may be largely responsible for the increased renal vascular resistance of hemorrhagic hypotension. On the other hand, Rector et al. (4) observed intracortical blood flow redistribution during hemorrhage, but none during norepinephrine or angiotensin infusion. This suggested that the observed hemorrhagic intrarenal redistribution was due to factors other than humoral release of either norepinephrine or angiotensin. Grandchamp et al. (5) have suggested that the simultaneous action of both norepinephrine and local angiotensin are needed to produce the intrarenal blood flow redistribution of hemorrhagic hypotension.


Hemorrhagic Shock Renin Secretion Renal Vascular Resistance Vasopressor Agent Renal Oxygenation 
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  1. 1.
    Watts, D.T., and V. Westfall. Studies on peripheral blood catecholamine levels during hemorrhagic shock in dogs. Proc. Soc. Exptl. Biol. Med. 115: 601–604, 1964.Google Scholar
  2. 2.
    Scornik, O.A., and A.C. Paladini. Angiotensin blood levels in hemorrhagic hypotension and other related conditions. Am. J. Physiol. 206: 553–556, 1964.PubMedGoogle Scholar
  3. 3.
    Aukland, K. Kidney circulation during hemorrhagic hypotension. In: Microcirculation as Related to Shock, edited by D. Shepro, and G.P. Fulton. New York: Academic Press, 1968, p. 121–135.CrossRefGoogle Scholar
  4. 4.
    Rector, J.B., J.H. Stein, W.H. Bay, R.W. Osgood, and T.F. Ferris. Effect of hemorrhage and vasopressor agents on distribution of renal blood flow. Am. J. Physiol. 222: 1125–1131, 1972.PubMedGoogle Scholar
  5. 5.
    Grandchamp, A., R. Veyrat, E. Rosset, J.R. Scherrer, and B. Truniger. Relationship between renin and intrarenal hemodynamics in hemorrhagic hypotension. J. Clin. Invest. 50: 970–978, 1971.PubMedCrossRefGoogle Scholar
  6. 6.
    Strauss, J., A.V. Beran, C.T. Brown, and N. Katurich. Renal oxygenation under “normal” conditions. Am. J. Physiol. 215:1482–1487, 1968.PubMedGoogle Scholar
  7. 7.
    Strauss, J., A.V. Beran, R. Baker, L. Boydston, and J.L. Reyes-Sanchez. Effect of hemorrhagic shock on renal oxygenation. Am. J. Physiol. 221: 1545–1550, 1971.PubMedGoogle Scholar
  8. 8.
    Kramer, K., and P. Deetjen. Oxygen consumption and sodium reabsorption in the mammalian kidney. In: Oxygen in the Animal Organism, edited by F. Dickens, and E. Neil. New York: Macmillan, 1964, p. 411–431.Google Scholar
  9. 9.
    Munck, O., N.A. Lassen, P. Deetjen, and K. Kramer. Evidence against renal hypoxia in acute haemorrhagic shock. Arch. Ges. Physiol. 274: 356–363, 1962.CrossRefGoogle Scholar
  10. 10.
    Schrier, R.W. Effects of adrenergic nervous system and catecholamines on systemic and renal hemodynamics, sodium and water excretion and renin secretion. Kidney Internat. 6: 291–306, 1974.CrossRefGoogle Scholar
  11. 11.
    Cannon, P.J., R.P. Ames, and J.H. Laragh. Indirect action of angiotensin infusion to inhibit renal tubular sodium re-absorption in dogs. Am. J. Physiol. 211: 1021–1030, 1966.PubMedGoogle Scholar
  12. 12.
    Bradley, S.E., and J.B. Coelho. Renal pharmacology of “shock” and its congeners. In: Drugs Affecting Kidney Function and Metabolism. Progress in Biochemical Pharmacology Vol. 7, edited by K.D.G. Edwards, and R. Paoletti. Basel: S. Karger, 1972, p. 1–58.Google Scholar
  13. 13.
    Strauss, J., A.V. Beran, and R. Baker. Fabrication of electrodes for continuous tissue O2 monitoring. J. Appl. Physiol. 37: 988–990, 1974.PubMedGoogle Scholar
  14. 14.
    Granger, P., J.M. Rojo-Ortega, A. Gruener, H. Dahlheim, K. Thurau, R. Boucher, and J. Genest. On the intrarenal role of the renin angiotensin system. In: Control of Renin Secretion: Experimental Medicine and Biology, Vol. 17, edited by T.A. Assaykeen. New York: Plenum Press, 1972, p. 131–144.CrossRefGoogle Scholar
  15. 15.
    Brown, J.J., D.L. Davies, A.F. Lever, R.A. Parker, and J.I.S. Robertson. The assay of renin in single glomeruli in the normal rabbit and the appearance of the juxtaglomerular apparatus. J. Physiol. 176: 418–428, 1965.Google Scholar
  16. 16.
    Innes, I.R., and M. Nickerson. Drugs acting on postganglionic adrenergic nerve endings and structures innervated by them (Sympathomimeteic drugs). In: The Pharmacological Basis of Therapeutics, edited by L.S. Goodman, and A. Gilman. The Mac millan Company, 1969, p. 477–520.Google Scholar
  17. 17.
    Hornych, H., M. Beaufils, and G. Richet. The effect of exogenous angiotensin on superficial and deep glomeruli in the rat kidney. Kidney Internat. 2: 336–343, 1972.CrossRefGoogle Scholar
  18. 18.
    Wathen, R.L., W.S. Kingsbury, D.A. Stouder, E.G. Schneider, and H.H. Rostorfer. Effects of infusion of catecholamines and angiotensin II on renin release in anesthetized dogs. Am. J. Physiol. 209: 1012–1024, 1965.PubMedGoogle Scholar
  19. 19.
    Dell, R.B., and R.W. Winters. Lactate gradients in the kidney of the dog. Am. J. Physiol. 213: 301–307, 1967.PubMedGoogle Scholar
  20. 20.
    Strauss, J., A.V. Beran, N. Katurich, and C.T. Brown. Renal regional O2 consumption under “normal” and hemorrhagic shock conditions. (Abstract). Am. Soc. Nephrol., Los Angeles, October 1967, p. 63.Google Scholar
  21. 21.
    Gill, J.R., and A.G.T. Casper. Effect of renal alpha-adrenergic stimulation on proximal tubular sodium reabsorption. Am. J. Physiol. 223: 1201–1205, 1972.PubMedGoogle Scholar
  22. 22.
    Lockett, M.F. Actions of adrenal, hypophysial and renal hormones on the renal excretion of water and electrolytes. In: Drugs Affecting Kidney Function and Metabolism. Progress in Biochemical Pharmacology, Vol. 7, edited by KDG Edwards and R. Paolettio Basel: S. Karger, 1972, p. 94–145.Google Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Rex Baker
    • 1
    • 2
  • Anthony V. Beran
    • 1
    • 2
  • Jose Strauss
    • 1
    • 2
  1. 1.Departments of PediatricsUniversity of Miami School of MedicineMiamiUSA
  2. 2.California College of MedicineU.C. IrvineIrvineUSA

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