Effect of Vasopressors and Hemorrhage on Intrarenal Oxygenation
Hemorrhagic hypotension has been reported to be accompanied by liberation of catecholamines (1) and angiotensin (2). Aukland observed parallel blood flow decreases in cortex and outer medulla during hemorrhage and the injection of various vasopressor agents (3). From these data he suggested that vasopressors may be largely responsible for the increased renal vascular resistance of hemorrhagic hypotension. On the other hand, Rector et al. (4) observed intracortical blood flow redistribution during hemorrhage, but none during norepinephrine or angiotensin infusion. This suggested that the observed hemorrhagic intrarenal redistribution was due to factors other than humoral release of either norepinephrine or angiotensin. Grandchamp et al. (5) have suggested that the simultaneous action of both norepinephrine and local angiotensin are needed to produce the intrarenal blood flow redistribution of hemorrhagic hypotension.
KeywordsHemorrhagic Shock Renin Secretion Renal Vascular Resistance Vasopressor Agent Renal Oxygenation
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