The O2 Supply of the Isolated Cell-Free Perfused Rat Kidney

  • H. Franke
  • Ch. Weiss
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 75)


Compared to the organ in situ in all isolated cell-free perfused kidney preparations so far described tubular net sodium transport is considerably reduced (1, 2, 3, 4, 5). Since the active tubular transport of sodium is a basic function of the mammalian kidney a number of other dysfunctions of isolated kidneys may be caused by the reduced rate of sodium transport.


Proximal Tubule Colloidosmotic Pressure Mammalian Kidney Micropuncture Study Circle Curve 
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  1. (1).
    Cuypers, Y., Nizet, A., Baerten, A.: Technique pour la perfusion de reins isoles de chien avec du sang heparine. Arch. Inter. Physiol. Biochem. 72,245 (1964)CrossRefGoogle Scholar
  2. (2).
    Franke, H., Huland, H., Weiss, Ch., Unsicker, K.: Improved net sodium transport of the isolated rat kidney. Z.Ges. exp. Med. 156, 268 (1971)Google Scholar
  3. Huland, H., Seitz, H.J., Tarnowski, W., Weiss, Ch,: The fuels of respiration of the isolated perfused rat kidney. Life Sciences l4, 117 (1974)CrossRefGoogle Scholar
  4. (4).
    Schurek, H.J., Brecht, J.P., Lohfert, H., Hierholzer, K.: The basic requirements for the function of the isolated cell free perfused rat kidney. Pflügers Arch. (im Druck)Google Scholar
  5. (5).
    Waugh, W.H., Kubo, T.: Development of an isolated perfused dog kidney with improved function. Amer. J. Physiol. 217, 277 (1969)PubMedGoogle Scholar
  6. (6).
    Bahlmann, J., Giebisch, G., Ochwadt, B., Schoppe,W.: Micropuncture study of isolated perfused rat kidney. Amer. J. Physiol. 212, 77 (1967)PubMedGoogle Scholar
  7. (7).
    Bowman, R.H., Maack, T.: Effect of albumine concentration and ADH on H2O and electrolyte transport in perfused rat kidney. Amer. J. Physiol. 226, 426, (1974)PubMedGoogle Scholar
  8. (8).
    Michael, U.F., Barenberg, R.L., Chavez, R., Vaamonde, C.A., Pappers, S.: Renal handling of sodium and water in the hypothyroid rat. Clearance and micropuncture studies. J. Clin. Invest. 51 1405 (1972)PubMedCrossRefGoogle Scholar
  9. (9).
    Ross, B.d., Epstein, F.H. and Leaf, A.: Sodium reabsorption in the perfused rat kidney. Amer. J. Physiol. 225, 1165 (1973)PubMedGoogle Scholar
  10. (10).
    Schurek, H.J., Brecht, J. P., Brand, P., Lange, K., Kolbe, H., Keller, K.: Substrate action on transport and metabolism of the isolated perfused rat kidney (Action of pyruvate oxaloacetate, butyrate and succinate). In: Sympos. Biochem. aspects of renal function. Salzburg Ed. by M. Hohenegger, 110, Goldmann-Verlag München (1972)Google Scholar
  11. (11).
    Leichtweiss, H.P., Lübbers, D.W., Weiss, Ch., Baumgärtl, H., Reschke, W.: The oxygen supply of the rat kidney measurements of intrarenal pO2. Pflügers Arch. 309, 328 (1969)PubMedCrossRefGoogle Scholar
  12. (12).
    Baumgärtl, H., Leichtweiss, H.-P., Lübbers, D.W., Weiss, Ch., Huland, H.: The oxygen supply of the dog kidney: measurements of intrarenal pO2. Microvasc. Res. 4, 247 (1972)PubMedCrossRefGoogle Scholar
  13. (13).
    Cain, H., Pacecas, St.: Studien über die Folgen einer vorübergehenden experimentellen Nierenischaemie I. Die morphologischen Veränderungen des akuten Schadens und ihre funktionelle Bedeutung. Virchows. Arch. path. Anat. 336, 389, (1963)Google Scholar
  14. (14).
    Thoenes, W.: Feinstrukturen des normalen und funktionsgestörten Nephrons. Verh. Dtsch. Ges. Path. 49. Tagung, 14 (1965)Google Scholar
  15. (15).
    Little, J.R., Cohen, J.J.: Effect of albumine concentration on function of isolated perfused rat kidney. Amer. J. Physiol. 226, 512 (1974)PubMedGoogle Scholar
  16. (16).
    Trimble, M.E., Bowman, R.H.: Na and K transport: effects of glucose, palmitate and -bromopalmitate. Amer. J. Physiol. 225, 1057 (1973)PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • H. Franke
    • 1
  • Ch. Weiss
    • 1
  1. 1.Physiologisches InstitutUniversität KielKielGermany

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