Autonomic and Pharmacological Control of Oxygen Autoregulation Mechanisms in Brain Tissue
In previous publications (1,3) we have described a precisely controlled autoregulatory mechanism to maintain a constant brain TpO2 level. This includes a theoretical “tissue oxygen sensor” able to simultaneously regulate cerebral blood flow and tissue O2 consumption through reflex inhibition-excitation of generalized neuronal activity; it is defined by four criteria in the physiological compensatory response elicited by a short period of anoxic anoxia: 1) short “reoxygenation time” (RT, the time required for TpO2 to return to the pre-anoxic level), 2) increase in cerebral blood flow, 3) presence of an “overshoot” (period after reoxygenation during which TpO2 is higher than baseline, and 4) a period of “anoxic silence” in neuronal activity.
KeywordsCerebral Blood Flow Brain Oxygen Brain Tissue Oxygenation Carotid Blood Flow TpO2 Level
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