Autonomic and Pharmacological Control of Oxygen Autoregulation Mechanisms in Brain Tissue

  • H. I. Bicher
  • P. Marvin
  • D. Hunt
  • D. F. Bruley
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 75)


In previous publications (1,3) we have described a precisely controlled autoregulatory mechanism to maintain a constant brain TpO2 level. This includes a theoretical “tissue oxygen sensor” able to simultaneously regulate cerebral blood flow and tissue O2 consumption through reflex inhibition-excitation of generalized neuronal activity; it is defined by four criteria in the physiological compensatory response elicited by a short period of anoxic anoxia: 1) short “reoxygenation time” (RT, the time required for TpO2 to return to the pre-anoxic level), 2) increase in cerebral blood flow, 3) presence of an “overshoot” (period after reoxygenation during which TpO2 is higher than baseline, and 4) a period of “anoxic silence” in neuronal activity.


Cerebral Blood Flow Brain Oxygen Brain Tissue Oxygenation Carotid Blood Flow TpO2 Level 
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  1. 1.
    Bicher, H.I. Brain autoregulation: A protective reflex to hypoxia. Microvascular Research, 8:291–313, 1974.PubMedCrossRefGoogle Scholar
  2. 2.
    Bicher, H.I., Bruley, D.F., Reneau, D.D. and Knisely, M.H. Effect of microcirculation changes on brain tissue oxygenation. J. Physiol., 217:689–707, 1971.PubMedGoogle Scholar
  3. 3.
    Bicher, H.I. Reneau, D.D., Bruley, D.F. and Knisely, M.H. Brain oxygen supply and neuronal activity under normal and hypoglycemic conditions. Am. J. Physiol., 224: 275–282, 1973.PubMedGoogle Scholar
  4. 4.
    Bicher, H.I., Reneau, D.D., and Knisely, M.H. Brain tissue oxygenation as determined with a new ultramicro oxygen electrode. In: Blood Oxygenation, (D. Hershey, ed.). pp. 201–207, Plenum Press, New York, 1970.CrossRefGoogle Scholar
  5. 5.
    Bicher, H.I., Rubin, J.W. and Adams, R.J. Clinical use of a new intra-arterial catheter electrode system. In: Oxygen Transport to Tissue: Instrumentation, Methods, and Physiology. (H.I. Bicher, and D.F. Bruley, eds.), pp. 107–113, Plenum Press, New York, 1973.Google Scholar
  6. 6.
    Bicher, H.I. and Knisely, M.H. Brain tissue reoxygenation, demonstrated with a new ultramicro oxygen electrode. J. AppL. Physiol., 28:387–390, 1970.PubMedGoogle Scholar
  7. 7.
    Lubbers, D.W. Personal communication.Google Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • H. I. Bicher
    • 1
  • P. Marvin
    • 1
  • D. Hunt
    • 1
  • D. F. Bruley
    • 2
  1. 1.Dept. Pharmacol.Univ. Ark. Med. CenterLittle RockUSA
  2. 2.Dept. Chem. Engin.Tulane Univ.New OrleansUSA

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