Comparison of Oxygen Tension in the Spinal Cord and Globus Pallidus During Hyperbaric Oxygen Exposure of Rats Under Pentobarbital Anesthesia
Lesions in the brain and spinal cord have been produced by exposing rats to hyperbaric oxygen. Complete or partial necrosis of nuclear groups with damage to myelin, axons and glia have been produced consistently in the globus pallidus and spinal cord gray matter of unanesthetized rats after intermittent exposures to 100% oxygen at 60 P.S.I.G. (Pounds per Square Inch by the Guage).1,2 Pentobarbital anesthesia has been found to protect the globus pallidus from the necrotic lesions of hyperbaric oxygen, but it potentiates lesions of the spinal cord.3 In exploration of the causal mechanism of these lesions, we have previously reported direct measurements of oxygen tensions in the globus pallidus of rats anesthetized with pentobarbital and compressed to 60 P.S.I.G. with 100% oxygen.4 Oxygen tensions up to 475 mmHg were recorded within five minutes after achieving a pressure of 60 P.S.I.G. The oxygen tensions then fell to an average value of 60 mmHg within 45 minutes.
KeywordsSpinal Cord Oxygen Tension Globus Pallidus Hyperbaric Oxygen Necrotic Lesion
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