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An Analysis of Ion Distribution in Brain Following Anoxia

  • D. Reneau
  • T. Zeuthen
  • E. Dóra
  • I. Silver
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 75)

Abstract

Experimental measurements of changes in the extracellular ion concentrations of rat brain cortex have been made with ultrami croelectrodes (1). During extended anoxia of several minutes duration, the changes in ionic concentrations may be characterized by the following statements:
  1. (1)

    Changes occurred in two phases: A preanoxic depolarization phase and an anoxic depolarization phase.

     
  2. (2)

    The preanoxic depolarization phase was characterized by small increases in extracellular Na+, K+, Cl- concentrations and usually a slight decrease in brain DC potential.

     
  3. (3)

    The anoxic depolarization phase was characterized by wery rapid increases in extracellular K+, simultaneous decreases in Na+ and Cl-, and rapid decreases in DC potential.

     

Keywords

Intracellular Region Minute Duration Active Trans Port Process Mathematical Consideration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. (1).
    Zeuthen, T., and E. Dora: Brain Metabolism and Ion Movements in Brain Cortex of the Rat During Anoxia, Proceedings of the International Workshop on Ion Selective Electrodes, Ulm, Germany (In Press).Google Scholar
  2. (2).
    Brace, R. A., and D. K. Anderson: J. Applied Physiol., 35, 90–94, 1973.Google Scholar
  3. (3).
    Reneau, D. D.: A Mathematical Analysis of Simultaneous Transport Phenomena in the Microcirculation, Proceedings of the International Workshop on Ion Selective Electrodes, Ulm, Germany (In Press).Google Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • D. Reneau
    • 1
  • T. Zeuthen
    • 2
  • E. Dóra
    • 2
  • I. Silver
    • 3
  1. 1.Department of Biomedical EngineeringLouisiana Tech UniversityRustonUSA
  2. 2.Department of Comparative PathologyBristol UniversityBristolEngland
  3. 3.Department of PhysiologySemmelweis UniversityBudapestHungary

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