Abstract
This investigation concerns the brain tissue response to variations in carotid artery pO2. A theoretical model was developed and several experimental methods employed to produce dynamic arterial pO2 changes in intubated cats, outlined as follows:
Method | Experiments |
|---|---|
Changes in Inspired O2 | Hyperoxic Step Changes |
(air → 95% O2–5% CO2) | |
Hypoxic Step Changes | |
(air → N2, or O2-CO2 mixtures → N2) | |
Oscillating Changes ≤ 0.1 Hz | |
(air → N2, or O2-CO2 mixtures → N2) | |
Blood Exchange System | Hypoxic Changes |
Oscillating Changes ≤ 1.0 Hz | |
Pseudo-Random Noise Changes |
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© 1976 Plenum Press, New York
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Dorson, W.J., Bogue, B.A. (1976). Theoretical and Experimental Aspects of Brain Tissue Oxygenation Dynamics. In: Grote, J., Reneau, D., Thews, G. (eds) Oxygen Transport to Tissue — II. Advances in Experimental Medicine and Biology, vol 75. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3273-2_41
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DOI: https://doi.org/10.1007/978-1-4684-3273-2_41
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