Abstract
Pronounced increases in CBF occur in arterial hypoxia (see, for example Kety and Schmidt 1948, Cohen et al. 1967). The mechanisms of this hyperemia have never been clarified but it has been postulated that a decreased extracellular pH is responsible. The following evidence has been quoted in favour of this hypothesis. First, pronounced increases in CBF are observed in hypercapnia and hypoxia, conditions that are associated with cerebral acidosis. Second, in hypoxic hypoxia CBF increases when arterial PO2 is reduced below about 50 mm Hg (Courtice 1941, McDowall 1966, Kogure et al. 1970) and, at this degree of hypoxia, there is also accumulation of lactic acid in the tissue (Gurdjian et al. 1944, Siesjö and Nilsson 1971). Third, it has been reported that induced hypoglycemia, by limiting the supply of glucose for cerebral glycolysis, prevents the increase in CBF which otherwise occurs in hypoxia (Kogure et al. 1970).
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References
Bachelard, H. S., L. D. Lewis, U. Pontén and B. K. Siesjö, Mechanisms activating glycolysis in the brain in arterial hypoxia. J. Neurochem. 1974. 22. 395–401.
Borgström, L., H. Jóhannsson and B.K. Siesjö, The influence of acute normovolemic anemia on cerebral blood flow and oxygen consumption of anaesthetized rats. Acta physiol. scand. 1975. In press.
Borgström, L., H. Jòhannsson and B. K. Siesjö, The relationship between arterial PO2 and cerebral blood flow in hypoxic hypoxia. Acta physiol. scand. 1975. In press.
Cohen, P. J., S. C. Alexander, T. C. Smith, M. Reivich and H. Wollman, Effects of hypoxia and normocarbia on cerebral blood flow and metabolism in conscious man. J. appl. Physiol. 1967. 23. 183–189.
Courtice, F. C., The effect of oxygen lack on the cerebral circulation. J. Physiol. 1941. 100. 198–211.
Duffy, T. E., S. R. Nelson and O. H. Lowry, Cerebral carbohydrate metabolism during acute hypoxia and recovery. J. Neurochem. 1972. 19. 959–977.
Eklöf, B., N.A. Lassen, L. Nilsson, K. Norberg, B. K. Siesjö and P. Torlöf, Regional cerebral blood flow in the rat measured by the tissue sampling technique; a criticial evaluation using four indicators C14-antipyrine, C14 -ethanol, H -water and Xenon133. Acta physiol. scand. 1974. 91. 1–10.
Folbergrová, J., B. Ljunggren, K. Norberg and B. K. Siesjö, Influence of complete ischemia on glycolytic metabolites, citric acid cycle intermediates, and associated amino acids in the rat cerebral cortex. Brain Res. 1974. 80. 265–279.
Gurdjian, E. S., W. E. Stone and J. E. Webster, Cerebral metabolism in hypoxia. Arch. Neurol. Psychiat. 1944. 51. 472–477.
Häggendal, E. and B. Norbäck, Effect of blood viscosity on cerebral blood flow. Acta chir. scand. 1966. Suppl. 364. 13–22.
Jóhannsson, H. and B. K. Siesjö, Blood flow and oxygen consumption in the rat brain in dilutional anemia. Acta physiol. scand. 1974. 91. 136–138.
Jóhannsson, H. and B. K. Siesjö, Cerebral blood flow and oxygen consumption in the rat in hypoxic hypoxia. Acta physiol. scand. 1975. In press.
Kety, S.S. and C. F. Schmidt, The effects of altered arterial tensions of carbon dioxide and oxygen on cerebral oxygen consumption of normal young men. J. clin. Invest. 1948. 27. 484–492.
Kogure, K., P. Scheinberg, O. M. Reinmuth, M. Fujishima and R. Busto, Mechanisms of cerebral vasodilatation in hypoxia. J. appl. Physiol. 1970. 29. 223–229.
Landau, W. M., W. H. Freygang, Jr., L. P. Rowland, L. Sokoloff and S. S. Kety, The local circulation of the living brain; values in unanesthetized and anesthetized cat. Trans. Amer, neurol. Ass. 1955. 80. 125–129.
Lewis, L. D., B. Ljunggren, R. A. Ratcheson and B. K. Siesjö, Cerebral energy state in insulin-induced hypoglycemia, related to blood glucose and to EEG. J. Neurochem. 1974. 23. 673–679.
McDowall, D. G., Interrelationships between blood oxygen tension and cerebral blood flow. In: Oxygen Measurements in Blood and Tissues, ed. J. P. Payne and D. W. Hill. pp. 205–214. Churchill, London 1966.
Nilsson, B., Measurement of overall blood flow and oxygen consumption in the rat brain. Acta physiol. scand. 1974. 92. 142–144.
Nilsson, B., K. Norberg, C. -H. Nordstrom and B. K. Siesjö, Influence of hypercapnia and hypoxia on CBF in rats. 7th Intern. Symp. on Cerebral Circulation and Metabolism, Aviemore, Scotland. Submitted for publication.
Norberg, K. and B. K. Siesjö, Quantitative measurement of blood flow and oxygen consumption in the rat brain. Acta physiol. scand. 1974. 91. 154–164.
Norberg, K. and B. K. Siesjö, Cerebral metabolism in hypoxic hypoxia. I. Pattern of activation of glycolysis; a re-evaluation. Brain Res. 1975. In press.
Norberg, K. and B. K. Siesjö, Cerebral metabolism in hypoxic hypoxia. II. Citric acid cycle intermediates and associated amino acids. Brain Res. 1975. In press.
Norberg, K., B. Quistorff and B. K. Siesjö, Effects of short-term hypoxia on energy metabolism in the cerebral cortex of unanaesthetized and anaesthetized rats. Brain Res. Submitted for publication.
Paulson, O. B., H.H. Parving, J. Olesen and E. Skinhj, Influence of carbon monoxide and of hemodilution on cerebral blood flow and blood gases in man. J. appl. Physiol. 1973. 36. No. 1. 111–116.
Ponte, J. and M. J. Purves, The role of the carotid body chemoreceptors and carotid sinus baroreceptors in the control of cerebral blood vessels. J. Physiol. (Lond.) 1974. 237. 315–340.
Pontén, U., R. A. Ratcheson, L. G. Salford and B. K. Siesjö, Optimal freezing conditions for cerebral metabolism in rats. J. Neurochem. 1973. 21. 1127–1138.
Reivich, M., J. Jehle, L. Sokoloff and S. S. Kety, Measurements of regional cerebral blood flow with antipyrine 14C in awake cats. J. appl. Physiol. 1969. 27. 296–300.
Siesjö, B. K. and L. Nilsson, The influence of arterial hypoxemia upon labile phosphates and upon extracellular and intracellular lactate and pyruvate concentration in the rat brain. Scand. J. Clin. Lab. Invest. 1971. 27. 83–96.
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© 1976 Plenum Press, New York
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Siesjö, B.K., Borgström, L., Jóhannsson, H., Nilsson, B., Norberg, K., Quistorff, B. (1976). Cerebral Oxygenation in Arterial Hypoxia. In: Grote, J., Reneau, D., Thews, G. (eds) Oxygen Transport to Tissue — II. Advances in Experimental Medicine and Biology, vol 75. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3273-2_40
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