Cerebral Oxygen Supply in Brain Edema and During Ventriculo-Cisternal Perfusion

  • J. Grote
  • R. Schubert
  • A. Fenske
  • J. Brantzen
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 75)


Numerous brain injuries and brain tumors lead to edema in brain tissue which can have consequences for the oxygen supply to the damaged tissue as well as to adjacent tissue areas. In studies made of the blood flow and oxygen supply in perifocal edematous tissue of brain tumors and lesions in patients undergoing various brain operations a direct relationship between the regional blood flow and the water content could be demonstrated (3). As the water content of the tissue increased, the blood flow through it diminished. In many cases, the reduction of the blood flow in the brain tissue induced an insufficient oxygen supply. In the tissue samples under investigation, the CrP and ATP concentrations were diminished in comparison to normal brain tissue. At the same time a marked rise in the lactate concentration and the lactate-pyruvate ratio was determined. The studies in patients were the starting point for further animal experiments.


Cerebral Blood Flow Brain Edema Oxygen Uptake Rate Regional Blood Flow Sinus System 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • J. Grote
    • 1
  • R. Schubert
    • 1
  • A. Fenske
    • 1
  • J. Brantzen
    • 1
  1. 1.Departments of Applied Physiology and NeurosurgeryUniversity of Mainz65 MainzGermany

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