A Theoretical Model of the Respiratory Function of Blood
The physiology and pathophysiology of oxygen transport as mediated by changes in erythrocyte acid-base status and organic phosphate content have been subjects of intense research activity in recent years. These endeavors have been inspired by the discovery of the dramatic effect of changes in red cell 2,3 diphosphoglycerate (DPG) concentration upon hemoglobin oxygen affinity (3,4), and such clinical observations as the inverse relationship between the amounts of DPG and hemoglobin in the blood of anemic patients (5,9). However, in the face of insufficient as well as conflicting data, the significance of changes in the oxygen affinity of hemoglobin as an adaptive mechanism for the maintenance of sufficient oxygen supply remains a matter of speculation (see, for example, the reviews of Bellingham, Rørth, and Woodson in ref. 6).
KeywordsOxygen Affinity Capillary Transit Time Sufficient Oxygen Supply Alveolar Carbon Dioxide Hemoglobin Oxygen Affinity
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- 6).L. Garby (ed.) (1974). Clinics in Hematology 3, 575–720.Google Scholar
- 7).Guest, G.M. and S. Rapoport (1939). Am. J. Dis. Child 58, 1072.Google Scholar
- 8).Hill, E.P., Power G.G. and L.D. Longo (1973). Am. J. Physiology 224, 904.Google Scholar
- 9).M. Hjelm (1969). Försvarsmedicin 5, 219.Google Scholar
- 13).J.H. Meldon, manuscript in preparation.Google Scholar
- 14).Meldon, J.H. and L. Garby (1975). Acta Med. Scand. Suppl. 578, in press.Google Scholar
- 15).Shaw, L.A. and A.C. Messer (1932). Am. J. Physiol. 100, 122.Google Scholar
- 16).J.H.M. was supported by Nat. Heart and Lung Institute (USA) Postdoctoral Fellowship 5 F02 HL54901–02.Google Scholar