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The Induction of Cytochrome P-450 by Hypoxia

  • I. S. Longmuir
  • Laura Pashko
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 75)

Abstract

A number of apparently unrelated observations have led us to look for daily fluctuations in the level of liver cytochrome P-450. We have observed that there seems to be a rather wide variation in P-450 concentrations in different animals of the same sex, age, and species. In addition the Chouteau phenomenon is pronounced in men after midnight, whereas the same stress has no effect in the afternoon. The third observation is that the response to certain drugs is greater in man after midnight than during the day, whereas in nocturnal species the same phenomenon is seen twelve hours out of phase. Since cytochrome P-450 appears to play an important role in both tissue oxygen transport and drug inactivation, these latter effects could be associated with a diurnal variation in the concentration of this pigment.

Keywords

Continuous Light Daily Fluctuation Liver Cytochrome Nocturnal Species Lung Diffuse Capacity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bishop, J. M., K. W. Donald, and O. L. Wade (1955) J. Clin. Invest. 34:1114.PubMedCrossRefGoogle Scholar
  2. Estabrook, R. W., A. Sligematsu, and J. B. Schenkman (1970) Advances in Enzyme Regulation 8: 121.PubMedCrossRefGoogle Scholar
  3. Longmuir, I. S. (1970) 6th Europ. Conf. Microcirculation, Aalborg. (Karger, Basel) p. 3.Google Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • I. S. Longmuir
    • 1
  • Laura Pashko
    • 1
  1. 1.Department of BiochemistryNorth Carolina State UniversityRaleighUSA

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