The Effect of Red Cell 2,3-DPG Changes Induced by Diabetic Ketoacidosis on Parameters of the Oxygen Dissociation Curve in Man

  • Eberhard Standl
  • Jørn Ditzel
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 75)

Abstract

As early as in 19 39 Guest and Rapoport reported a striking decrease of the red cell 2,3-diphosphoglycerate (2,3-DPG) concentration in patients suffering from severe diabetic ketoacidosis (1). This observation has been amply confirmed in more recent years (2,3,4,5), when interest was resurrected to investigate the regulation of red cell 2,3-DPG after Benesch and Benesch (6) and Chanutin and Curnish (7) had shown the effect of 2,3-DPG on the oxygen affinity of hemoglobin. 2,3-DPG is formed as an intermediary product of red cell glycolysis; increase in hydrogen-ion concentration decreases red cell glycolysis mainly through inhibition of the phosphofructokinase step (8) and it has been widely accepted that the remarkable low erythrocyte 2,3-DPG levels in diabetic ketoacidosis — as little as 2o per cent of the normal concentration is observed — are due to this mechanism and an additional inhibition of di-phosphoglycerate mutase at lower pH (9).

Keywords

Phosphorus Anemia Syringe Dehydration Carbamate 

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References

  1. 1.
    Guest, G.M., Rapoport, S.: Am.J.Dis.Child. 58, 1072, 1939.Google Scholar
  2. 2.
    Bellingham, A.J., Detter, J.C., Lenfant, C.: Trans. Ass.Am.Phys. 83, 113, 1970.Google Scholar
  3. 3.
    Alberti, K.G.M.M., Darley, J.H., Emerson, P.M., Hockaday, T.D.R.: Lancet 1972 II, 391.CrossRefGoogle Scholar
  4. 4.
    Ditzel, J.: Advanc.Exp.Med.Biol. 37 A, 163, 1973.Google Scholar
  5. 5.
    Ditzel, J.: Horm.Metabol.Res. 5, 471, 1973.CrossRefGoogle Scholar
  6. 6.
    Benesch, R., Benesch, R.E.: Biochem.Biophys.Res. Commun. 26, 162, 1967.PubMedCrossRefGoogle Scholar
  7. 7.
    Chanutin, A., Curnish, R.R.: Arch.Biochem.Biophys. 121, 96, 1967.PubMedCrossRefGoogle Scholar
  8. 8.
    Rapoport, S.: in Campbell, P.N., Greville,G.D. (eds): Essays of Biochemistry 4, 69, New York, Academic Press, 1968.Google Scholar
  9. 9.
    Rose, Z.B.: Arch.Biochem.Biophys. 138, 903, 1973.CrossRefGoogle Scholar
  10. 10.
    Kühn, B., Jacobasch, G., Gerth, C., Rapoport, S.M.: Eur.J.Biochem. 43, 437, 1974.PubMedCrossRefGoogle Scholar
  11. 11.
    Rapoport, S., Maretzki, D., Schewe, C.: in Rørth, M., Astrup, P. (ed.) Oxygen affinity of hemoglobin and red cell acid base status, p. 527–538. Copenhagen: Munksgaard, New York: Academic Press 1972Google Scholar
  12. 12.
    Bauer, Ch.: Life Sci. 8, 1o41, 1969.CrossRefGoogle Scholar
  13. 13.
    Benesch, R.E., Benesch, R., Yu, C.I.: Biochemistry 8, 2567, 1969.PubMedCrossRefGoogle Scholar
  14. 14.
    Siggaard-Andersen, O., Sailing, N.: Scand.J.Clin. Lab.Invest. 27, 361, 1971.PubMedCrossRefGoogle Scholar
  15. 15.
    Tomita, S., Riggs, A.: J.Biol.Chem. 246, 547,1971.PubMedGoogle Scholar
  16. 16.
    Duhm, J.: in Bicher, H.I., Bruley, D.F. (ed.) Oxygen transport to tissue, p. 179–186. New York: Plenum Publishing Corporation 1972Google Scholar
  17. 17.
    Parekh, A.C., Jung, D.H.: Clin.Chim.Acta 27, 373, 1970.PubMedCrossRefGoogle Scholar
  18. 18.
    Ericsson, A., de Verdier, C.H.: Scand.J.Clin.Lab. Invest. 29, 85, 1972.CrossRefGoogle Scholar
  19. 19.
    Duvelleroy, M.A., Buckles, R.C., Rosenkaimer, S., Tung, C., Laver, M.A.: J. Appl. Physiol. 28, 227, 1970.PubMedGoogle Scholar
  20. 20.
    Riggs, A.: Proc.Nat.Acad.Sci. 68, 2062, 1971.PubMedCrossRefGoogle Scholar
  21. 21.
    Benesch, R., Benesch, R.E., Yu, C.J.: Proc.Nat. Acad.Sci. 59, 526, 1968.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Eberhard Standl
    • 1
  • Jørn Ditzel
    • 1
  1. 1.Department of Medicine, Aalborg Regional Hospital, Denmark and Diabetes Research UnitCity Hospital SchwabingMunichGermany (FRG)

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