Copper Content of Indoleamine 2,3-Dioxygenase

  • F. Hirata
  • T. Shimizu
  • R. Yoshida
  • T. Ohnishi
  • M. Fujiwara
  • O. Hayaishi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 74)

Abstract

Indoleamine 2,3-dioxygenase is a hemoprotein which catalyzes the oxygenative ring cleavage of substituted and unsubstituted indoleamines such as tryptophan, 5-hydroxytryptophan, tryptamine and serotonin (1). This enzyme utilizes superoxide anion (O2 -) as an oxidizing agent (2).

Keywords

Cellulose Superoxide Sedimentation Electrophoresis Serotonin 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Hirata, F., and Hayaishi, O. (1972) Biochem. Biophys. Res. Commun. 47, 1112–1119PubMedCrossRefGoogle Scholar
  2. 2.
    Hirata, F., and Hayaishi, O. (1975) J. Biol. Chem. 250, 5960–5966PubMedGoogle Scholar
  3. 3.
    Brady, O. F. (1975) FEBS Letters 57, 237–240PubMedCrossRefGoogle Scholar
  4. 4.
    Hayaishi, O., Hirata, F., Ohnishi, T., Yoshida, R., and Shimizu, T., presented in this meetingGoogle Scholar
  5. 5.
    Brady, O. F., Manaco, E. M., Forman, J. H., Schutz, G., and Feigelson, P. (1972) J. Biol. Chem. 247, 7915–7922PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • F. Hirata
    • 1
  • T. Shimizu
    • 1
  • R. Yoshida
    • 1
  • T. Ohnishi
    • 1
  • M. Fujiwara
    • 1
  • O. Hayaishi
    • 1
  1. 1.Department of Medical Chemistry, Faculty of MedicineKyoto UniversityKyotoJapan

Personalised recommendations