A New Assay Procedure for Indoleamine 2,3-Dioxygenase
Indoleamine 2,3-dioxygenase is a heme-containing dioxygenäse that catalyzes the oxygenative ring cleavage of various substituted and unsubstituted indoleamines, such as tryptophan, 5-hydroxytryptophan, tryptamine, serotonin and so forth. The product of the reaction was identified to be the corresponding formylanthraniloyl-alkylamine (Fig. 1). This enzyme is ubiquitously distributed in various organs of mammals and appears to play an important role in the metabolism of these biogenic indoleamines.
KeywordsSuperoxide Dismutase Methylene Blue Glutathione Reductase Xanthine Oxidase Assay Procedure
Unable to display preview. Download preview PDF.