Advertisement

A New Assay Procedure for Indoleamine 2,3-Dioxygenase

  • O. Hayaishi
  • F. Hirata
  • T. Ohnishi
  • R. Yoshida
  • T. Shimizu
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 74)

Abstract

Indoleamine 2,3-dioxygenase is a heme-containing dioxygenäse that catalyzes the oxygenative ring cleavage of various substituted and unsubstituted indoleamines, such as tryptophan, 5-hydroxytryptophan, tryptamine, serotonin and so forth. The product of the reaction was identified to be the corresponding formylanthraniloyl-alkylamine (Fig. 1). This enzyme is ubiquitously distributed in various organs of mammals and appears to play an important role in the metabolism of these biogenic indoleamines.

Keywords

Superoxide Dismutase Methylene Blue Glutathione Reductase Xanthine Oxidase Assay Procedure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Hirata, F., and Hayaishi, O. (1971) J. Biol. Chem. 246, 7825–7826PubMedGoogle Scholar
  2. 2.
    Hirata, F., and Hayaishi, O. (1975) J. Biol. Chem. 250, 5960–5966PubMedGoogle Scholar
  3. 3.
    Peterkofsky, B. (1968) Arch. Biochem. Biophys. 128, 637–645PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • O. Hayaishi
    • 1
  • F. Hirata
    • 1
  • T. Ohnishi
    • 1
  • R. Yoshida
    • 1
  • T. Shimizu
    • 1
  1. 1.Department of Medical Chemistry, Faculty of MedicineKyoto UniversitySakyo-ku, Kyoto 606Japan

Personalised recommendations