On the Participation of Cytochrome P-450 in the Mechanism of Prevention of Hepatic Carcinogenesis

  • A. N. Saprin
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 74)


The microsomal mixed-function oxidase system metabolizes many compounds with different chemical structures and biological activity i.e. carcinogens, drugs, poisons, etc. (1–4). The terminal oxidase of the microsomal electron transfer system — cytochrome P-450 — plays an important role in these processes as has been shown by many investigators over the past few years (3,4).


Terminal Oxidase Free Radical Concentration Carcinogenic Polycyclic Aromatic Hydrocarbon Hepatic Carcinogenesis Lipid Peroxide Radical 
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  1. 1.
    Conney, A.K., Miller, E.C., Miller, J.A., Cancer Res., 1956, 16, 450.PubMedGoogle Scholar
  2. 2.
    Gillette, J.R. In: Advances in Pharmacology, v. 4. Academic Press, New York, 1966, pp. 219–261.CrossRefGoogle Scholar
  3. 3.
    Gelboin, H.V. In: Advances in Cancer Research, v. 10, Academic Press Inc., New York and London, 1967, pp. 9–91.Google Scholar
  4. 4.
    Maslova, Y.M., Reichman, L.M., Skulachev, V.P. Uspechi sovremennoi biologii, U.S.S.R., 1969, 67, 400.Google Scholar
  5. 5.
    Miller, E.C., Miller, J.A., Brown, R.R., McDonald, Y.C., Cancer Res., 1958, 18, 469.PubMedGoogle Scholar
  6. 6.
    Cramer, J.W., Miller, J.A., Miller, E.C. J. Biol. Chem., 1960, 235, 250.PubMedGoogle Scholar
  7. 7.
    Gelboin, H.V., Kinoshita, N., Wiebel, F.J. In: Environment and Cancer (24 Annual Symposium on Fundamental Cancer Research, 1971), The Williams and Wilkins Como. 1972, pp. 476.Google Scholar
  8. 8.
    Magee, P.N., Barnes, J.M. In: Advances inCancer Research, v. 10, Academic Press, New York — London, 1967, pp. 242–323.Google Scholar
  9. 9.
    Gelboin, H.V., Kinoshita, N., Wiebel, F.J. Fed. Proc., 1972, 31, 1298.PubMedGoogle Scholar
  10. 10.
    Omura, T., Sato, T., J. Biol. Chem., 1964, 239, 2370.Google Scholar
  11. 11.
    Miyake, Y., Mason, H.S., Landgraf, W., J. Biol. Chem., 1967, 242, 393.PubMedGoogle Scholar
  12. 12.
    Miyake, Y., Gayler, J.L., Mason, M.S., J. Biol. Chem., 1968, 243, 5788.PubMedGoogle Scholar
  13. 13.
    Ichikawa, J., Yamano, T. Biochim. at Biophys. Acta 1968, 153, 753.CrossRefGoogle Scholar
  14. 14.
    Emanuel, N.M., Saprin, A.N., Shuljakovskaja, T.S., Kozlova, L.E., Bunto, T.V., Dokladi Academii Nauk U.S.S.R., 1973, 209, 1449.Google Scholar
  15. 15.
    Saprin, A.N., Gurevitch, S.M., Zvegintseva, E.Y., Dokladi Academii Nauk, U.S.S.R., 1973, 208, 973.Google Scholar
  16. 16.
    Vladimirov, Ju.A., Archakov, A.I. In: The Peroxide Oxidation of Lipids in Biological Membranes, Moscow, 1972.Google Scholar
  17. 17.
    Levin, W., Lu, A.Y.M., Jacobson, M. et al. Archives of Biochem. and Biophys., 1973, 158, 842.CrossRefGoogle Scholar
  18. 18.
    Emanuel, N.M., Lipchina, L.P. Dokl. Acad. Nauk, U.S.S.R., 1958, 121, 141.Google Scholar
  19. 19.
    Frankfurt, O.S., Lipchina, L.P., Bunto, T.V., Emanuel, N.M., Bull. Exp. Biol. Med. (U.S.S.R.), 1967, 8, 163.Google Scholar
  20. 20.
    Gilbert, D., Goldberg, L. Food Cosmet. Toxicol. 1965, 3, 417.PubMedCrossRefGoogle Scholar
  21. 21.
    Creaven, P.J., Davies, W.H., Williams, R.T., J. Pharmacol., 1966, 18, 485.CrossRefGoogle Scholar
  22. 22.
    Martin, A.D., Gilbert, D. Biochem. J., 1968, 106, 22.Google Scholar
  23. 23.
    Gilbert, D., Martin, A.D., Gargolli, S.D. et al. Food Cosmet. Toxicol., 1969, 7, 603.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • A. N. Saprin
    • 1
  1. 1.Cancer Center of HawaiiHonoluluUSA

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