The Role of Cytochrome P-450 in the Regulation of Steroid Biosynthesis

  • Peter F. Hall
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 74)


A mitochondrial cytochrome P-450 catalyzes the conversion of cholesterol to pregnenolone in the various steroid-forming organs: pregnenolone is converted to the steroid hormones secreted by these organs. The conversion of cholesterol to pregnenolone is commonly called side-chain cleavage (Figure 1). Side-chain cleavage appears to determine the rate of steroid biosynthesis so that the role of P-450 in that reaction is important in considering the regulation steroid production in the whole animal (1–3).


Sucrose Density Gradient Steroid Biosynthesis Additional Utilization Steroid Hydroxylation Adrenodoxin Reductase 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Peter F. Hall
    • 1
  1. 1.Department of PhysiologyUniversity of CaliforniaIrvineUSA

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