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Highly Purified Cytochrome P-450 from Liver Microsomal Membranes: Recent Studies on the Mechanism of Catalysis

  • M. J. Coon
  • D. P. Ballou
  • F. P. Guengerich
  • G. D. Nordblom
  • R. E. White
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 74)

Abstract

The purpose of this paper is to summarize our knowledge of the properties of purified liver microsomal cytochrome P-450, including evidence for multiple forms, and to present data from recent experiments bearing on the mechanism of action of this cytochrome. For the sake of brevity we will confine our discussion to studies in this laboratory on cytochrome P-450 solubilized and purified from rabbit liver microsomes.

Keywords

Difference Spectrum Cyanogen Bromide Cumene Hydroperoxide United States Public Health Benzyl Ether 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • M. J. Coon
    • 1
  • D. P. Ballou
    • 1
  • F. P. Guengerich
    • 1
  • G. D. Nordblom
    • 1
  • R. E. White
    • 1
  1. 1.Department of Biological Chemistry, Medical SchoolThe University of MichiganAnn ArborUSA

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