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Kinins pp 59-64 | Cite as

The Regulation of Kallikrein Secretion from Isolated Submandibular Gland Slices by Neurotransmitters, Cyclic Nucleotides and Calcium

  • K. D. Bhoola
  • P. F. Heap
  • M. J. C. Lemon
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 70)

Abstract

Evidence suggests that neurotransmitters interact with specific receptors on the plasma membrane of cells which results in the formation within the cell of a chemical messenger. Enzyme secretion in exocrine glands is considered to be controlled by the chemical messengers, adenosine 3′5′ monophosphate (cyclic AMP), guanosine 3′5′ cyclic monophosphate (cyclic GMP) and calcium. This second messenger concept was examined using isolated guinea-pig submandibular gland slices, incubated in modified Krebs-Ringer at 37°C and gassed with a mixture of 95% 02–5% CO2 (Fig. 1). The secretion of kallikrein into the incubation medium together with the morphological changes which accompany the secretory process were determined in response to noradrenaline, acetylcholine, dibutyryl cyclic AMP and dibutyryl cyclic GMP.

Keywords

Acinar Cell Secretory Granule Cyclic Nucleotide Enzyme Secretion Exocrine Gland 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bhoola, K.D. & Lemon, M.J.C. (1975). J. Physiol. (Lond) 245, 121–122P.Google Scholar
  2. Lemon, M.J.C. & Bhoola, K.D. (1975). Biochem. Biophys. Acta. 385, 101–113.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • K. D. Bhoola
    • 1
  • P. F. Heap
    • 1
  • M. J. C. Lemon
    • 1
  1. 1.Departments of Pharmacology and Anatomy, The Medical SchoolUniversity of BristolBristolUK

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