The Effect of Water, Sodium Overloading and Diuretics upon Urinary Kallikrein
Urinary kallikrein is significantly decreased in different types of experimental (Croxatto and San Martin, 1970; Margolius et al., 1972), clinical (Margolius. et al., 1972; Adetuyibi and Mills, 1972; Greco et al., 1974) and spontaneous hypertension (Porcelli et al., 1975). In contrast to the numerous reports dealing with alterations in kallikrein excretion, there is still meager information concerning the physiological role of the kallikrein-kinin system in the kidney. Although renal kallikrein appear to be directly related to sodium excretion (Marin-Grez and Carretero, 1972; Adetuyibi and Mills, 1972), other data have been published suggesting that not Na, but mineralocorticoids are the primary factor regulating kallikrein excretion (Geller et al., 1972; Pisano et al., 1974; Margolius, et al., 1974). Other results indicate a functional relationship between kallikrein and water excretion (Mills and Ward, 1975). In addition it has been proposed that renal kallikrein, acting either locally in the kidney (Pisano et al., 1974), and/or systemically (Croxatto, 1972 a,b) can be part of the vasodilator system.
KeywordsSodium Excretion Water Excretion Spontaneous Hypertension Urinary Kallikrein Enzyme Excretion
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- 3.Croxatto, H.R., and G. Noe. Kallikrein like enzyme in purified renal extracts containing renin. Commentarii Pontif. Acad. Scient. 40: 1 (1971).Google Scholar
- 4.Croxatto, H.R. Rinon y sistema calicreina-cininas. Medicina (B. Aires) 72 (Supl. I) 18: 29 (1972,a)Google Scholar
- 5.Croxatto, H.R. Calicreina versus renina? Rev. Med. de Chile, 100: 708–717 (1972,b).Google Scholar
- 7.Croxatto, H.R., R. Albertini, J. Roblero and J. Corthorn. Renal kallikrein (kininogenase activity) in hypertensive rats. Acta Physiol. Lat. 24: 439–442 (1974).Google Scholar
- 8.Garcia, R.L., J. Roblero, and H.R. Croxatto. Antibodies of rat urinary kallikrein, preparation and specificity. Acta physiol. Latinoam. 23: 149–151 (1973).Google Scholar
- 11.Jacobsen, S. and M. Krisz. Some data on two purified kininogens from human plasma. Br. J. of Pharmac. Chemother. 29: 25–36 (1967).Google Scholar
- 17.Pisano, J.J., R. Geller, H.S. Margolius and H.S. Keiser. Urinary kallikrein in hypertensive rats. Acta Physiol. Latinoamer 24: 73–78 (1974).Google Scholar
- 18.Porcelli, G., G. Bianchi and H.R. Croxatto. Urinary kalli-krein excretion in a spontaneously hypertensive strain of rats. Proc. Soc. of Exp. Biol. and Med. (in press) (1975).Google Scholar
- 19.Roblero, J.S., H.R. Croxatto, J. Corthorn, R. Garcia and E. De Vito. Kininogenase activity in urine and perfusion fluid of isolated rat kidney. Acta Physiol. Latinoamer 23: 154–156 (1973).Google Scholar
- 21.Rosas, R., L. Barnafi, T. Pereda, and H.R. Croxatto. Effect of oxytocin structural changes on rat renal excretion of Na, K and water. Am. J. of Physiol. 202: 901 (1962).Google Scholar