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Kinins pp 329-333 | Cite as

Urinary Excretion of Kallikrein Following Myocardial Infarction

  • P. L. Del Bianco
  • C. Curradi
  • G. De Saint Pierre
  • G. Nava
  • F. Sicuteri
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 70)

Abstract

Several years ago, the implication of the kallikrein-kinin system was hypothesized in the pathogenesis of pain and shock during myocardial infarction (1). This hypothesis was then confirmed by our first observation that demonstrated a significant decrease of the plasmatic kininogen level in infarcted patients in the first few days of the disease (2). Furthermore, our experiences (3,4) and those of other authors (5,6) confirmed these first observations.

Keywords

Myocardial Infarction Cardiogenic Shock Urinary Kallikrein Kinin System Kallikrein Inhibitor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Bibliography

  1. 1.
    Sicuteri F.: “La mediazione chimica del dolore coronarico” Mal. Cardiovasc, suppl. 2e, 37, 1964.Google Scholar
  2. 2.
    Sicuteri F., Franchi G., Del Bianco P.L., and Fanciullaci M.: “Some physiological and pathological roles of kininogen and kinin”, in Proc. Int. Symp. “Hypotensive Peptides”, Springer Verlag, ed., 525, 1966.Google Scholar
  3. 3.
    Sicuteri F., Franchi G., Del Bianco P.L., and Del Bene E.: “A contribution to the interpretation of shock and pain in myocardial infarction”, Mal. Cardiovasc, 8, 3, 1967.Google Scholar
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    Sicuteri F., Del Bianco P.L., and Fanciullacci M.: “Kinins in the pathogenesis of cardiogenic shock and pain”, Adv. Exp. Med. Biol., 9, 315, 1970.Google Scholar
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    Massion W.H., Blumel G., and Peschl L.: “The role of plasma kinin system in cardiogenic shock and related conditions”, Proc. Int. Symp. “Proteases and Antiproteases in Cardioangiology”, Vietri Sul Mare, Italy 1969, F.K. Schattauer Verlag, Stuttgart, N.Y., 81, 1969.Google Scholar
  6. 6.
    Kirnura E.: “Changes of Kinin system and hemodynamics in acute stage of myocardial infarction”, Proc. Int. Symp. on “Trasylol and Experimental Myocardial Infarction”, Dusseldorf, January, 1975. (in press).Google Scholar
  7. 7.
    Sicuteri F., Antonini F.M., Del Bianco P.L., Franchi G.C., and Curradi C: “Prekallikrein and kallikrein inhibitor in plasma of patients affected by recent myocardial infarction”, Adv. Exp. Med. Biol., 21, 445, 1972.CrossRefGoogle Scholar
  8. 8.
    Porcelli G.: “Progress on urinary kallikrein tests”. “Kinin 75” Int. Symp., Florence, Italy, 1975. (in press).Google Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • P. L. Del Bianco
    • 1
  • C. Curradi
    • 1
  • G. De Saint Pierre
    • 2
  • G. Nava
    • 1
  • F. Sicuteri
    • 1
  1. 1.Department of Clinical PharmacologyUniversity of FlorenceItaly
  2. 2.Santa Maria Nuova HospitalFlorenceItaly

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