Kinins pp 319-321 | Cite as

Action of U. V. Rays on the Experimental Cutaneous Inflammation Induced by Cantharidin

  • R. Galletti
  • L. Matassi
  • P. Chiarini
  • F. Corti
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 70)

Abstract

In previous researches in man, it was demonstrated that histamine injected i.v. in microdoses (40 μg) reactivates a decreasing cutaneous inflammation. It is well known that the experimental inflammation induced on the skin by application of cantharidin presents the following characteristics (Fig. 1): 1.) development of exudate; 2.) sensation of pain that starts about 10 hours after the application of the stimulus; 3.) halo of hyperemia corresponding to primary hyperalgesia; 4.) a larger area of secondary hyperalgesia. After 48 hours all these elements are strongly reduced: this shows how inflammation is fading. In this phase an intravenous histamine administration is followed by a new increase of blister exudate, hyperemic halo and secondary hyperalgesia. A short-lasting burning pain in the blister also arises. At the same time, the kininogen level in the blister exudate increased.

Keywords

Burning Polypeptide Histamine Corti Cantharidin 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • R. Galletti
    • 1
  • L. Matassi
    • 1
  • P. Chiarini
    • 1
  • F. Corti
    • 1
  1. 1.Dept. of MedicineUniversity of FlorenceItaly

Personalised recommendations