Action of U. V. Rays on the Experimental Cutaneous Inflammation Induced by Cantharidin
In previous researches in man, it was demonstrated that histamine injected i.v. in microdoses (40 μg) reactivates a decreasing cutaneous inflammation. It is well known that the experimental inflammation induced on the skin by application of cantharidin presents the following characteristics (Fig. 1): 1.) development of exudate; 2.) sensation of pain that starts about 10 hours after the application of the stimulus; 3.) halo of hyperemia corresponding to primary hyperalgesia; 4.) a larger area of secondary hyperalgesia. After 48 hours all these elements are strongly reduced: this shows how inflammation is fading. In this phase an intravenous histamine administration is followed by a new increase of blister exudate, hyperemic halo and secondary hyperalgesia. A short-lasting burning pain in the blister also arises. At the same time, the kininogen level in the blister exudate increased.
KeywordsPain Sensation Specific Antagonist Experimental Inflammation Burning Pain Kinin Concentration
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