Kinins pp 315-318 | Cite as

Leukokinins — Clinical Entities of Neoplasia?

  • Lowell M. Greenbaum
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 70)


Leukokinins are high molecular weight polypeptides which our laboratory first described. They are potent pharmacological mediators released by an acid protease found in white cells and neoplastic cells. The name leukokinin is derived from leuko — or white cells, the initial source of the enzyme. However, they were also found in L-1210 cells, a human leukemia-derived tumor as well as other tumor cells. Since these polypeptides resembled brady-kinin in their pharmacological properties the class of peptides were named leukokinins.


Ovarian Carcinoma Ascites Fluid Fluid Accumulation Acid Protease Human Preparation 
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  1. 1.
    Greenbaum, L.M. Leukocyte Kininogenases and Leukokinins from Normal and Malignant Cells. Am. J. Pathol. 68: 613–623, 1972.PubMedGoogle Scholar
  2. 2.
    Greenbaum, L.M. Cellular Kininogenases and Leukokinins. Int’l. Conf. on Chem. and Biol. of the Kallekrein-Kinin System in Health Disease. 1974, in press.Google Scholar
  3. 3.
    Greenbaum, L.M., Grebow, P., Johnston, M., Prakash, A. and Semente, G. Pepstatin, An Inhibitor of Leukokinin Formation and Ascitic Fluid Accumulation. Cancer Res. 35: 706–710, 1975.PubMedGoogle Scholar
  4. 4.
    Greenbaum, L.M., Prakash, A., Semente, G. and Johnston, M. The Leukokinin System; Its Role in Fluid Accumulation in Malignancy and Inflammation. In: Agents and Actions, 3:332–334, 1973. ed: Birkhauser Verlag Basel.PubMedCrossRefGoogle Scholar
  5. 5.
    Johnston, M. and Greenbaum, L.M. Leokokinin-Forming System in the Ascitic Fluid of a Murine Mastocytoma. Biochem. Pharmacol. 22: 1386–1389, 1973.PubMedCrossRefGoogle Scholar
  6. 6.
    Spragg, J. The Plasma Kinin-Forming System. In Mediators of Inflammation. ed.: Weissman, J. Plenum Press, 1974.Google Scholar
  7. 7.
    Greenbaum, L.M. Cathepsin D-generated, Pharmacologically Active Peptides (Leukokinins) and Their Role in Ascites Fluid Accumulation. Cold Spring Harbor Laboratory Symposium on Proteases and Biological Control, 223, 1975.Google Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Lowell M. Greenbaum
    • 1
  1. 1.Department of PharmacologyColumbia UniversityNew YorkUSA

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