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Kinins pp 229-234 | Cite as

Histamine and Kallikrein System in Man

  • F. Pedata
  • P. L. Del Bianco
  • C. Curradi
  • B. Anselmi
  • F. Sicuteri
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 70)

Abstract

Histamine is a well-known pain producing substance; and its acute administration in essential headache provokes or exacerbates the ache; the chronic administration of histamine can improve headache, probably through a sort of desensitization at the level of the nociceptors. Other pain producing substances, such as kinins, can take part in the mechanism of the histamine desensitization; in fact, histamine and the histamine liberator 48/80, when acutely administered, are able to lower the plasma kininogen level in man (1). Interactions between histamine and the kailikrein-kinin system have been shown by other authors (2,3,4,5,6).

Keywords

Nicotinic Acid Kallikrein Inhibitor Serum Trypsin Essential Headache Histamine Liberator 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • F. Pedata
    • 1
  • P. L. Del Bianco
    • 1
  • C. Curradi
    • 1
  • B. Anselmi
    • 1
  • F. Sicuteri
    • 1
  1. 1.Department of Clinical PharmacologyUniversity of FlorenceItaly

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