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Kinins pp 191-196 | Cite as

Biochemical Actions of Fibroblast Kinin-Forming Protease

  • Hsin C. Li
  • William F. McLimans
  • Nathan Back
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 70)

Abstract

Both a neutral (1) and acid (2,3) protease capable of forming kinins from a variety of mammalian substrates have been isolated and purified from the transplanted rodent Murphy-Sturm lymphosarcoma (MSLS). The MSLS tissue was comprised of a neterogeneous population of tumor cells and fibroblasts. Initial studies with a pure cell line of mouse fibroblasts grown in stationary cell culture identified the presence of a kinin-forming protease active optimally at pH 4.0.

Keywords

Acid Protease Fold Purification Rodent Fibroblast Kinin Formation Form Protease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Hsin C. Li
    • 1
  • William F. McLimans
    • 2
  • Nathan Back
    • 1
  1. 1.Department of Biochemical Pharmacology, School of PharmacyState University of New YorkUSA
  2. 2.Department of Cell PhysiologyRoswell Park Memorial InstituteBuffaloUSA

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