Kinins pp 191-196 | Cite as

Biochemical Actions of Fibroblast Kinin-Forming Protease

  • Hsin C. Li
  • William F. McLimans
  • Nathan Back
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 70)


Both a neutral (1) and acid (2,3) protease capable of forming kinins from a variety of mammalian substrates have been isolated and purified from the transplanted rodent Murphy-Sturm lymphosarcoma (MSLS). The MSLS tissue was comprised of a neterogeneous population of tumor cells and fibroblasts. Initial studies with a pure cell line of mouse fibroblasts grown in stationary cell culture identified the presence of a kinin-forming protease active optimally at pH 4.0.


Acid Protease Fold Purification Rodent Fibroblast Kinin Formation Form Protease 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Hsin C. Li
    • 1
  • William F. McLimans
    • 2
  • Nathan Back
    • 1
  1. 1.Department of Biochemical Pharmacology, School of PharmacyState University of New YorkUSA
  2. 2.Department of Cell PhysiologyRoswell Park Memorial InstituteBuffaloUSA

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