Kinins pp 157-175 | Cite as

Mechanism of Clostripain-Induced Kinin Release from Human, Rat and Canine Plasma

  • B. B. Vargaftig
  • E. L. Giroux
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 70)


Clostripain (clostridiopeptidase B, E.C. is a thiol proteinase found in extracts from cultures of Clostridium histolyticum (Ogle and Tytell, 1953; Labouesse and Gros, 1960), and displays a marked specificity for the carboxyl linkage of arginine (Gros and Labouesse, 1960; Mitchell and Harrington, 1968). Clostripain has been reported to release kinin-like polypeptides directly from bovine or horse kininogen-containing preparations (Prado, et al., 1956; Prado and Prado, 1962). In the course of investigations concerning the haemorrhagic and pro-inflammatory activity of bacterial collagenase (Giroux, Lefort and Vargaftig, 1976) we found that clostripain, a contaminant of one collagenase preparation, displayed indirect kinin-releasing activities which had not been described before. This communication reports our investigation of the mechanism of such release.


Trypsin Inhibitor Kinin Activity Amidase Activity Dexamethasone Phosphate Hexadimethrine Bromide 


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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • B. B. Vargaftig
    • 1
  • E. L. Giroux
    • 1
  1. 1.Centre de Recherche Merrell InternationalStrasbourgFrance

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