Kinins pp 81-95 | Cite as

Mechanism of the Sialagogic Effect Induced by Bradykinin in Dogs: Possible Mediation by Endogenous Prostaglandin

  • A. P. Corrado
  • M. Grellet
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 70)


The increase of the dog submaxillary gland secretion induced by bradykinin (3 μg/kg) by intracarotideal route is low, shortlasting and tachyphylatic. It is unaffected by hexamethonium (2 mg/kg, i.v.) and is still present in chronically denervated glands. The effect is abolished by atropine (1 mg/kg, i.V.), morphine (10 μg/kg, i.v.) or following the ganglionic block by depolarization induced by nicotine (1 mg) by intracarotideal route.


Salivary Flow Superior Cervical Ganglion Salivary Secretion Carotid Occlusion Lingual Artery 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • A. P. Corrado
    • 1
  • M. Grellet
    • 1
  1. 1.Departments of Pharmacology and Surgery, Faculty of Medicine of Ribeirao PretoUSPBrazil

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