Past, Present and Future of Kinins
It is a great pleasure to attend the demand of my friend Frederigo Sicuteri, to give a few Introductory Remarks to this Symposium that received the suggestive name of “Kinins-75”. With such a title for the Symposium, and the title I gave to this address: Past, Present and Future of Kinins, I feel like Fellini, and would like to call it “Kinin Amarcord”, to remind you of the early times of bradykinin, in the late 40’s, to be precise, May 1948, when with Beraldo and Rosenfeld, we fell upon an intriguing substance appearing in the blood of dogs which received an injection of the venom of Bothrops jararaca. A few weeks later we observed the appearance of a similar principle in the defibrinated blood of the dog, in experiments of liver perfusion.
KeywordsPolypeptide Histamine Alkaloid Acetylcholine Bradykinin
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