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Transport Mechanisms in the Cerebrospinal Fluid System for Removal of Acid Metabolites from Developing Brain

  • Norman H. Bass
  • Per Lundborg
Part of the Advances in Experimental Medicine and Biology book series (AEMB)

Abstract

Postnatal development of a “blood-brain-barrier” for protecting the central nervous system from fluctuating concentrations of charged lipophobic molecules in blood, parallels the maturation of unique and highly efficient transport mechanisms for the intracranial removal of organic acids3,4. Prior studies have clearly delineated anatomic barriers called “tight junctions” in brain capillaries which prohibit penetration of proteins having molecular diameters larger than 20 Å13. The permeability of this same barrier to smaller and more polar molecules has not been determined. Recent observations strongly suggest that homeostatic mechanisms designed to protect the internal milieu of brain may be viewed not only as a membranous barrier for blood-borne molecules based on their size, lipid solubility, and ionization constant, but as a series of selective filtration sites for carrier-mediated transport of watersoluble, polar molecules from the intracranial cavity into the systemic circulation13, 17.

Keywords

Choroid Plexus Acid Metabolite Bulk Flow Postnatal Development Brain Capillary 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

PAH

Para-aminohippuric Acid

5-HIAA

5-Hydroxyindoleacetic acid

CSF

Cerebrospinal Fluid

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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Norman H. Bass
    • 1
  • Per Lundborg
    • 2
  1. 1.Department of Neurology, School of MedicineUniversity of VirginiaCharlottesvilleUSA
  2. 2.Department of PharmacologyUniversity of GöteborgSweden

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