Uptake and Exchange of GABA and Glutamate in Isolated Nerve Endings
In the last years an increasing number of reports have favoured the concept that GABA and glutamate act as inhibitory and excitatory neurotransmitters respectively in the mammalian CNS11, 12, 25. One of the essential biochemical steps of neurotransmission is the rapid inactivation of the active substance liberated in the synaptic cleft. With the only known exception of acetylcholine, which is rapidly hydrolyzed by a specific enzyme, reuptake into the presynaptic terminal is considered as the major means for terminating the action of most other putative neurotransmitters11, 12, 21, 24, 37.
KeywordsNerve Ending Uptake System Synaptic Cleft Neurotransmitter Amino Acid Gaba Uptake
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