Uptake and Exchange of GABA and Glutamate in Isolated Nerve Endings

  • Giulio Levi
  • Ugo Poce
  • Maurizio Raiteri
Part of the Advances in Experimental Medicine and Biology book series (AEMB)


In the last years an increasing number of reports have favoured the concept that GABA and glutamate act as inhibitory and excitatory neurotransmitters respectively in the mammalian CNS11, 12, 25. One of the essential biochemical steps of neurotransmission is the rapid inactivation of the active substance liberated in the synaptic cleft. With the only known exception of acetylcholine, which is rapidly hydrolyzed by a specific enzyme, reuptake into the presynaptic terminal is considered as the major means for terminating the action of most other putative neurotransmitters11, 12, 21, 24, 37.


Nerve Ending Uptake System Synaptic Cleft Neurotransmitter Amino Acid Gaba Uptake 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Giulio Levi
    • 1
  • Ugo Poce
    • 1
  • Maurizio Raiteri
    • 2
  1. 1.Laboratory of Cell BiologyRomeItaly
  2. 2.Institute of PharmacologyCatholic UniversityRomeItaly

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