Abstract
Intercellular communication is a fundamental process underlying behavior. The importance of communication between neurons in determining behavior is undisputed, but recent evidence suggests that communication between glia and neurons and between glia and other cell types may be of significance in the modulation of behavior. It is well established that the principal mode of inactivation of neurotransmitters, other than acetylcholine, is by reuptake into presynaptic terminals1. However, the close spatial relationships, of neurons and glia, and the glial ensheathment of axons and synapses, suggest that glia, as well as neurons, may participate in the uptake of synaptically released neurotransmitters2, 3 In so far as synaptic transmission depends in part on levels of the transmitter in the cleft, rapid removal of transmitter, either by neurons or glia, will influence or modulate efficacy of transmission. To demonstrate a significant glial role in the modulation of synaptic transmission, it is first necessary to show that glial cells possess mechanisms for the accumulation of transmitter which are comparable in substrate affinity to the pumps present in the specific nerve endings using that transmitter.
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Haber, B., Hutchison, H.T. (1976). Uptake of Neurotransmitters and Precursors by Clonal Cell Lines of Neural Origin. In: Levi, G., Battistin, L., Lajtha, A. (eds) Transport Phenomena in the Nervous System. Advances in Experimental Medicine and Biology, vol 69. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-3264-0_14
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