Phylogeny of Functional Humoral Transplantation Immunity: Comparative Studies in Amphibians and Rodents

  • Nicholas Cohen
  • William M. BaldwinIII
  • V. Manickavel
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 64)


Mammalian transplantation alloantigens elicit complex immunoprotective and immunodestructive reactivities which can be demonstrated in vitro by cytotoxicity and blocking assays (1). The impact of these functionally disparate responses on the in vivo fate of transplants has been strongly evidenced by the dramatically prolonged (enhanced) survival or by the significantly accelerated rejection of test skin grafts on mice adoptively immunized with immune lymphoid cells or sera (2–4). In marked contrast to our emerging awareness that for mammals, the survival of allografts reflects a net immune response equal to the outcome of a dynamic balance between functionally opposing immune reactivities (5), has been our relative ignorance of whether humoral immunity plays a comparable role in regulating graft survival in ectothermic (cold-blooded) vertebrates. Indeed, we are cognizant of only a limited number of reports that transplants do evoke detectable alloantibodies in fish (6), salamanders (7) and frogs (8).


Graft Survival Skin Graft Chronic Rejection Cytosine Arabinoside Skin Allograft 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1975

Authors and Affiliations

  • Nicholas Cohen
    • 1
  • William M. BaldwinIII
    • 1
  • V. Manickavel
    • 1
  1. 1.Division of Immunology, Department of MicrobiologyUniversity of Rochester School of Medicine and DentistryRochesterUSA

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