Demonstration of an Inverse Relationship between Regenerative Capacity and Oncogenesis in the Adult Frog, RanaPipiens
In a series of 105 adult frogs (Rana pipiens) 19 sarcomas were induced at the implantation site of 3-methylcholanthrene pellets. Two tumors arose first in the control forelimbs, whereas 13 tumors arose first in the denervated forelimb. The remaining tumors occurred in a previously tumor-bearing frog. Ten months was the average latent period required until tumor formation occurred.
KeywordsRegenerative Capacity Implantation Site Nerve Supply Adult Frog Tricaine Methanesulfonate
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- 2.Needham, J., Proc. Royal Soc. Med., 29: 1577–1626 (1936).Google Scholar
- 9.Breedis, C., Can. Res., 12: 861–873 (1952).Google Scholar
- 10.Ingram, A. J., J. Embryol. and Exp. Morph. 26: 425–441 (1971).Google Scholar
- 11.Seilern-Aspang, F. and Kratochwil, K., J. Embryol. and Exp. Morph., 10: 337–363 (1962).Google Scholar