Demonstration of an Inverse Relationship between Regenerative Capacity and Oncogenesis in the Adult Frog, RanaPipiens

  • H. C. Outzen
  • R. P. Custer
  • R. T. Prehn
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 64)


In a series of 105 adult frogs (Rana pipiens) 19 sarcomas were induced at the implantation site of 3-methylcholanthrene pellets. Two tumors arose first in the control forelimbs, whereas 13 tumors arose first in the denervated forelimb. The remaining tumors occurred in a previously tumor-bearing frog. Ten months was the average latent period required until tumor formation occurred.


Regenerative Capacity Implantation Site Nerve Supply Adult Frog Tricaine Methanesulfonate 
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Copyright information

© Springer Science+Business Media New York 1975

Authors and Affiliations

  • H. C. Outzen
    • 1
  • R. P. Custer
    • 1
  • R. T. Prehn
    • 1
  1. 1.The Fox Chase Cancer CenterThe Institute for Cancer ResearchPhila.USA

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