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Synergistic and Antagonistic Effects of Mitogens on Proliferation of Lymphocytes from Spleens of Ranapipiens

  • A. Lakshma Reddy
  • Richard K. Wright
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 64)

Abstract

Phytomitogens such as phytohemagglutinin (PHA) and concanavalin A (Con A) bind to cell surface receptors of thymus-derived (T) and bone marrow-derived (B) lymphocytes but stimulate only T-cells to divide and transform into blast cells (1, 2, 3). These mitogens can also stimulate lymphocytes from fish (4, 5, 6, 7) and amphibians (8, 9, 10). In the absence of biological markers at this level of phylogeny, however, evidence is lacking as to whether the responding cells belong to specific lymphocyte subpopulations.

Keywords

Spleen Cell Mitogenic Response Human Peripheral Blood Lymphocyte Spleen Lymphocyte Cell Mitogen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1975

Authors and Affiliations

  • A. Lakshma Reddy
    • 1
  • Richard K. Wright
    • 1
  1. 1.Department of Microbiology and Immunology and Department of AnatomySchool of Medicine and Dental Research Institute, University of CaliforniaLos AngelesUSA

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