Bursal and Thymic Alloantigen Expression in Lymphoid Tissues of the Chicken

  • N. Donnelly
  • A. Brand
  • D. G. Gilmour
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 64)


Aves represent that point on the evolutionary tree where separation of lymphoid tissues into thymus-dependent (T cell) and thymus-independent (B cell) lymphoid systems has been compartmentalized to its fullest. Two primary lymphoid organs control differentiation of immunity in birds — the thymus governs development of lymphocytes primarily mediating cellular immune functions, while the bursa of Fabricius controls the maturation of antibody-forming cells (1, 2). The division into T and B cell systems is not as anatomically distinct in other vertebrates, but studies in a number of species indicate that functionally such compartmentalization does exist (3–6). Thus, although Aves present a unique opportunity for studying the relative contribution of T and B cells to immune functions, knowledge gained in this model system has far wider applicability.


Lymphoid Tissue Thymus Cell Lymphoid System Cellular Immune Function Peripheral Lymphoid Tissue 


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Copyright information

© Springer Science+Business Media New York 1975

Authors and Affiliations

  • N. Donnelly
    • 1
  • A. Brand
    • 2
  • D. G. Gilmour
    • 2
  1. 1.University of Rochester School of Medicine & DentistryRochesterUSA
  2. 2.New York University School of MedicineNew YorkUSA

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