Evolution of Conformational Flexibility of Immunoglobulin M
Since the initial observations of Heidelberger and Pederson (1) of a macroglobulin antibody against pneumococcus in the horse, IgM has been recognized as a major class of immunoglobulins in mammals as well as in vertebrates as phylogenetically distant as the elasmobranchii (2). In fact, IgM appears to be the first recognizable class to have evolved. It still is the first immunoglobulin to be synthesized in a mammalian immune response.
KeywordsConformational Flexibility Rigid Sphere Rotational Correlation Time Nurse Shark Segmental Flexibility
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