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Preliminary Structural Characterization of Pacific Hagfish Immunoglobulin

  • A. E. De Ioannes
  • W. H. Hildemann
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 64)

Abstract

The immune capacities of primitive fishes of the class Agnatha, the lamprey and the hagfish, have been under study for nearly a decade. Early results from Good and his collaborators suggested that lampreys, but not hagfish, possessed an adaptive immune response (1, 2). However, subsequent work of Linthicum and Hildemann (3) and Hildemann and Thoenes (4, 5) showed that hagfish (Eptatretus stoutii) could also respond specifically to certain immunogens and could reject allografts under appropriate conditions.

Keywords

Sodium Dodecyl Sulfate Light Chain Heavy Chain Sucrose Gradient Light Chain Region 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Papermaster, B.W., Condie, R.M., Finstad, J. and Good, R.A., J. Exp. Med. 119: 105 (1964).PubMedCrossRefGoogle Scholar
  2. 2.
    Good, R.A. and Papermaster, B.W., Advances in Immunol. 4: 115 (1964).Google Scholar
  3. 3.
    Linthicum, D.S. and Hildemann, W.H., J. Immunol. 105: 4 (1970).Google Scholar
  4. 4.
    Hildemann, W.H. and Thoenes, G.H., Transplantation 7: 506 (1969).PubMedCrossRefGoogle Scholar
  5. 5.
    Thoenes, G.H. and Hildemann, W.H., In Developmental Aspects of Antibody Formation and Structure, Eds: J. Sterzl and I. Riha., 2: 711 (1969).Google Scholar
  6. 6.
    Marchalonis, J.J. and Edelman, G.M., J. Exp. Med. 127: 891 (1968).PubMedCrossRefGoogle Scholar
  7. 7.
    Litman, G.W., Frommel, D., Finstad, J., Howell, J., Pollara, B.A. and Good, R.A., J. Immunol. 105: 5 (1970).Google Scholar
  8. 8.
    Litman, G.W., Rosenberg, A. and Good, R.A., Federation Proc. 29: 774 (1970).Google Scholar
  9. 9.
    Clem, L.W. and Small, P.A., Jr., J. Exp. Med. 125: 893 (1967).PubMedCrossRefGoogle Scholar
  10. 10.
    Hirschfeld, J., In Handbook of Immunodiffusion and Immunoelectrophoresis, Ed: Ouchterlony (Ann Arbor Science Publishers, Ann Arbor, p.139, 1968).Google Scholar
  11. 11.
    Laemmeli, U.K. and Favre, M., J. Mol. Biol. 80: 575 (1973).CrossRefGoogle Scholar
  12. 12.
    Laemmeli, U.K., Nature, 227: 680 (1970).CrossRefGoogle Scholar
  13. 13.
    Atwell, J.L., The Structure and Evolution of Immunoglobulins. Ph.D. thesis submitted to the University of Melbourne (1974).Google Scholar
  14. 14.
    De Ioannes, A.E. and Hildemann, W.H., in preparation.Google Scholar
  15. 15.
    De Ioannes, A.E., Karp, R.D. and Hildemann, W.H., in preparation.Google Scholar
  16. 16.
    Spiegelberg, H.L., Nature 254: 723 (1975).PubMedCrossRefGoogle Scholar
  17. 17.
    Capra, J.D., Chuang, C., Kaplan, R.D. and Kehoe, J.M., Adv. Exp. Med. Biol. 45: 191 (1974).PubMedGoogle Scholar
  18. 18.
    Hildemann, W.H., Ann. Rev. Genetics 1: 19 (1973).CrossRefGoogle Scholar
  19. 19.
    Marchalonis, J.J., In Progress in Immunology II, vol. 2, p. 249, Eds: I. Brent and J. Holborow (1974).Google Scholar
  20. 20.
    Edmundson, A.B., Ely, K.R., Girling, R.L., Abola, E.E., Shiffer, M. and Westholm, F.A., In Progress in Immunology II, vol. 1, p. 103, Eds: I. Brent and J. Holborow (1974).Google Scholar
  21. 21.
    Edmundson, A.B., Ely, K.R., Girling, R.L., Abola, E.E., Shiffer, M., Westholm, F.A., Faush, M.D. and Doutch, H.F., Biochemistry 13: 3817 (1974).CrossRefGoogle Scholar
  22. 22.
    Metzger, H. and Singer, S.J., Science 142: 674 (1963).PubMedCrossRefGoogle Scholar
  23. 23.
    Fleishman, J.B., Pain, R. and Porter, R.R., Arch. Biochem. Biophys. Supply. 1: 174 (1962).Google Scholar
  24. 24.
    Shiffer, M., Girling, R.L., Ely, K.R., and Edmundson, A.B., Biochemistry 12: 4620 (1973).CrossRefGoogle Scholar
  25. 25.
    Williamson, A.R., Europ. J. Immunol. 1: 390 (1971).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1975

Authors and Affiliations

  • A. E. De Ioannes
    • 1
  • W. H. Hildemann
    • 1
  1. 1.Department of Microbiology and Immunology and Dental Research InstituteUniversity of CaliforniaLos AngelesUSA

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