Advertisement

Mechanism of Action of Hypolipidemic Drugs

  • C. R. Sirtori
  • D. Torreggiani
  • R. Fumagalli
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 63)

Abstract

Drugs may decrease serum lipid levels by impairing lipid absorption, lipoprotein synthesis or release, or by stimulating lipid or lipoprotein catabolism (45). Recent data point out, however, that agents such as Clofibrate (CPIB), generally thought to act only by inhibiting lipid and lipoprotein synthesis and release (3), may also affect lipid absorption.

Keywords

Hypolipidemic Effect Bile Acid Absorption HYPOLIPIDEMIC Drug Free Tryptophan Lipoprotein Synthesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Adams, L. L., Webb, W. W. and Fallon, H.J. J. Clin. Invest. 50: 2339, 1971.PubMedCrossRefGoogle Scholar
  2. 2.
    Albrink, M. J. and Klatskin, G. Ann. J. Med. 23:26, 1957.CrossRefGoogle Scholar
  3. 3.
    Avoy, D. R., Swyryd, E. A. and Gould, R. G. J. Lipid Res. 6: 369, 1965.PubMedGoogle Scholar
  4. 4.
    Azarnoff, D. L., Tucker, D. R. and Barr, G. A. Metabolism 14: 959, 1965.CrossRefGoogle Scholar
  5. 5.
    Baraona, E. and Lieber, C.S. J. Clin. Invest. 49: 769, 1970.PubMedCrossRefGoogle Scholar
  6. 6.
    Five-year study by a group of physicians of the Newcastle upon Tyne Region. British Medical J. 4: 767, 1971.CrossRefGoogle Scholar
  7. 7.
    Report of a Research Committee of the Scottish Society of Physicians. British Medical J. 4: 775, 1971.CrossRefGoogle Scholar
  8. 8.
    Brown, M. S. and Goldstein, J. L. Science 185:61, 1974.Google Scholar
  9. 9.
    Burch, R. E. and Curran, G. L. J. Lipid Res. 10:668, 1969.PubMedGoogle Scholar
  10. 10.
    Carlson, L. A., Walldius, G. and Butcher, R. W. Atherosclerosis 16: 349, 1972.CrossRefGoogle Scholar
  11. 11.
    Carlson, L.A. and Bottiger, L. E. Lancet i: 865, 1972.CrossRefGoogle Scholar
  12. 12.
    Chait, A., February, A. W., Mancini, M., and Lewis, B. Lancet 8: 62, 1972.CrossRefGoogle Scholar
  13. 13.
    Ciocia, D. and Cavalca, L. G. Arterioscler. 7: 1, 1969.Google Scholar
  14. 14.
    Di Luzio, N. R. and Zilversmit, D. B. Am. J. Physiol. 199: 991, 1960.Google Scholar
  15. 15.
    Di Luzio, N. R. Quart. J. Stud. Alcohol 23: 557, 1962.Google Scholar
  16. 16.
    Dujovne, C. A., Hurwitz, A., Kauffman, R. E. and Azarnoff, D.L. Clin. Pharmacol. Ther. 16: 291, 1974.PubMedGoogle Scholar
  17. 17.
    Eaton, R. P. Metabolism 22: 763, 1973.PubMedCrossRefGoogle Scholar
  18. 18.
    Eaton, R. P. J. Lipid Res. 14:312, 1973.PubMedGoogle Scholar
  19. 19.
    Eaton, R. P. and Schade, D. S. Metabolism 23: 445, 1974.CrossRefGoogle Scholar
  20. 20.
    Eccleston, D., Ashcroft, G.W. and Crawford, T. B. B. J. Neurochem. 12: 493, 1965.PubMedCrossRefGoogle Scholar
  21. 21.
    Edwards, K. D. G. and Paoletti, R. Med. J. Aust. 1:474, 1970.PubMedGoogle Scholar
  22. 22.
    Edwards, K. D. G. and Hawkins, M. R. Austr. N. Z. J. Med. 2: 104, 1972.Google Scholar
  23. 23.
    Elko, E. E., Wooles, W. R. and Di Luzio, N. R. Am. J. Physiol. 201: 923, 1961.PubMedGoogle Scholar
  24. 24.
    Gessa, G. L., Biggio, G. and Tagliamonte, A. Fed. Proc. 31: 599, 1972.Google Scholar
  25. 25.
    Goodman, D. S., Noble, R. P. and Dell, R. B. J. Clin. Invest. 52: 2646, 1973.PubMedCrossRefGoogle Scholar
  26. 26.
    Grundy, S. M., Ahrens, E. H., Salen, G., Schreibman, P. H., and Nestel, P.J. J. Lipid Res. 13:531, 1972.PubMedGoogle Scholar
  27. 27.
    Havel, R.J. and Kane, J. P. Ann. Rev. Pharmacol. 13:287, 1973.PubMedCrossRefGoogle Scholar
  28. 28.
    Hernell, O. and Johnson, O. Lipids 8: 503, 1973.PubMedCrossRefGoogle Scholar
  29. 29.
    Howard, A. N., Hyams, D. E., Everett, W., Jennings, I. W., Gresham, G. A., Bizzi, A., Garattini, S., Veneroni, E., and Miettinen, T. A. European J. Pharmacol. 13:244, 1971.CrossRefGoogle Scholar
  30. 30.
    Howard, A.N., Hyams, D.E. and Evans, R. C. Adv. Exp. Med. Biol. 26: 179, 1972.PubMedGoogle Scholar
  31. 31.
    Hunningghake, D. B. and Azarnoff, D.L. Metabolism 17: 588, 1968.CrossRefGoogle Scholar
  32. 32.
    Kahonen, M. T., Ylikahri, R. H. and Hassinen, I. Metabolism 21: 1021, 1972.PubMedCrossRefGoogle Scholar
  33. 33.
    Krasno, L. R. and Kidera, G.J. J. Am. Med. Ass. 219: 845, 1972.CrossRefGoogle Scholar
  34. 34.
    Kurup, C. K. R., Aithal, H. N., and Ramasarma, T. Biochem. J. 116: 773, 1970.PubMedGoogle Scholar
  35. 35.
    Lamb, R. G. and Fallon, H.J. J. Biol. Chem. 247: 1281, 1972.PubMedGoogle Scholar
  36. 36.
    Malloy, S. and Bloch, J. L. Am. J. Physiol. 184: 29, 1956.Google Scholar
  37. 37.
    Maragoudakis, M. E. J. Biol. Chem. 244:5005, 1969.PubMedGoogle Scholar
  38. 38.
    McMenamy, R. H. and Oncley, J. L. J. Biol. Chem. 233: 1436, 1958.PubMedGoogle Scholar
  39. 39.
    Pertsemlidis, D., Panveliwalla, D. and Ahrens, E. H. Gastroenterology 66: 565, 1974.PubMedGoogle Scholar
  40. 40.
    Platt, D.S. and Cockrill, B. L. Biochem. Pharmacol. 15: 927, 1966.PubMedCrossRefGoogle Scholar
  41. 41.
    Puglisi, C., Caruso, V., Conti, F., and Sirtori, C.R. Presented at the Fifth International Symposium on Drugs Affecting Lipid Metabolism, Milan, Italy, 1974.Google Scholar
  42. 42.
    Ryan, W. G. and Schwartz, T. B. Metab. (Clin. Exp.) 14: 1243, 1965.CrossRefGoogle Scholar
  43. 43.
    Samuel, P., Holtzman, C. H. and Goldstein, G. Circulation 35: 938, 1967.PubMedGoogle Scholar
  44. 44.
    Schapel, G. J., Edwards, K. D. G. and Neale, F. C. In: Progress in Biochemical Pharmacology, Volume 9, K. D. G. Edwards, editor. Karger, Basel, 1974, p. 82.Google Scholar
  45. 45.
    Sirtori, C. R., Fumagalli, R. and Paoletti, R. Adv. Exp. Med. Biol. 38: 171, 1973.PubMedGoogle Scholar
  46. 46.
    Sirtori, C. R., Agradi, E. and Mariani, C. Pharmacol. Res. Comm. 5: 81, 1973.CrossRefGoogle Scholar
  47. 47.
    Smith, H. G. and Lakatos, C. J. Pharm. Pharmacol. 23: 180, 1971.Google Scholar
  48. 48.
    Spano, P. F., Szyszka, K., Pozza, G., and Sirtori, C. R. Res. Exp. Med. 163: 65, 1974.CrossRefGoogle Scholar
  49. 49.
    Spano, P. F., Szyszka, K., Galli, C. L., and Ricci, A. Pharmacol. Res. Comm. 6: 163, 1974.CrossRefGoogle Scholar
  50. 50.
    Svoboda, D. and Azarnoff, D. L. J. Cell. Biol. 30:442, 1960.CrossRefGoogle Scholar
  51. 51.
    Tolman, E. L., Tepperman, H. M. and Tepperman, S. Am. J. Physiol. 218: 1313, 1970.PubMedGoogle Scholar
  52. 52.
    Westerfeld, W. W., Richert, D. A., and Ruegamer, W. R. Biochem. Pharmacol. 17: 1003, 1968.PubMedCrossRefGoogle Scholar
  53. 53.
    Wilson, D.E. and Lees, R. S. J. Clin. Invest. 51: 1051, 1972.PubMedCrossRefGoogle Scholar
  54. 54.
    Wolfe, B.M., Kane, J. P., Havel, R.J., and Brewster, H. P. J. Clin. Invest. 52: 2146, 1973.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • C. R. Sirtori
    • 1
  • D. Torreggiani
    • 1
  • R. Fumagalli
    • 2
  1. 1.Center “E. Grossi Paoletti” for the Study of Metabolic Diseases and HyperlipidemiasUniversity of MilanItaly
  2. 2.Institute of Pharmacology and PharmacognosyUniversity of MilanMilanItaly

Personalised recommendations