Advertisement

The Cockerel as an Animal Model for Atherosclerosis Research

  • Harry Y. C. Wong
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 63)

Summary

The chicken is a good animal model for the study of atherosclerosis research because it is:
  1. 1.

    Omnivorous.

     
  2. 2.

    Small and suitable for prolonged laboratory investigation.

     
  3. 3.

    Able to develop spontaneous atherosclerosis.

     
  4. 4.

    Capable of producing atherosclerosis after cholesterol feeding with elevated hypercholesterolemia. A diet of 1/4% cholesterol plus 5% cottonseed oil added to starter-grower-mash resulted in aortic atherosclerosis with a slight but significant increase in plasma cholesterol.

     
  5. 5.

    Plasma levels of cholesterol and triglyceride are similar to those in humans.

     
  6. 6.

    Lipid composition of high and low density lipoproteins as well as chylomicrons resembles those of humans.

     
  7. 7.

    Has been noted that there is no essential difference between vascular lesions seen in chickens as a result of cholesterol diet and that of atherosclerosis observed in man.

     

Keywords

Abdominal Aorta Plasma Cholesterol Cholesterol Diet Average Grade Atherogenic Diet 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Dauber, D. V. and Katz, L. N. Arch. Path. 34: 937, 1942.Google Scholar
  2. 2.
    Fox, H. In: Arteriosclerosis. E. V. Cowdry, editor, Macmillan, New York, pp. 153–193, 1933.Google Scholar
  3. 3.
    Dauber, D. V. Arch. Path. 38: 46, 1944.Google Scholar
  4. 4.
    Dauber, D. V. and Katz, L. N. Arch. Path. 36: 473, 1943.Google Scholar
  5. 5.
    Horlick, L. and Katz, L. N. Am. Heart J. 38: 336, 1949.PubMedCrossRefGoogle Scholar
  6. 6.
    Wong, H. Y. C., Johnson, F. B. and Wong, A. K. Circulation 16: 501, 1957.Google Scholar
  7. 7.
    Wong, H. Y. C., Wong, A. K. and Johnson, I. B. Circulation 18: No. 3, 482, 1958.Google Scholar
  8. 8.
    Wong, H. Y. C., Johnson, T. F. and Johnson, F. B. Proc. of 1st International Pharmacological Meeting, Vol. 2, Pergamon Press, Oxford, p. 115, 1963.Google Scholar
  9. 9.
    West, W. and Wong, H. Y. C. Proc. of 1st International Pharmacological Meeting, Vol. 2, Pergamon Press, Oxford, p. 99, 1963.Google Scholar
  10. 10.
    Wong, H. Y. C. and Johnson, F. B. Circulation Res. Vol. XI: 843, 1962.Google Scholar
  11. 11.
    Wong, H. Y. C. and Johnson, F. B. Fed. Proc. 26, No. 2: 489, 1967.Google Scholar
  12. 12.
    Wong, H. Y. C., David, S. and Orimilikwe, S. O. Fed. Proc. 32, No. 147: 1973.Google Scholar
  13. 13.
    Katz, L. N. and Stamler, J. Experimental Atherosclerosis. C. C. Thomas, Springfield, Illinois, p. 127, 1953.Google Scholar
  14. 14.
    Stamler, J. and Katz, L. N. Circulation 2: 705, 1950.Google Scholar
  15. 15.
    Kudzma, D. J., Hegstad, P.M. and Stoll, R. E. Metabolism 22: 423, 1973.CrossRefGoogle Scholar
  16. 16.
    Fredrickson, D. S., Levy, R. I. and Lees, R. S. New Engl. J. Med. 176: 148, 1967.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • Harry Y. C. Wong
    • 1
  1. 1.Department of Physiology, College of MedicineHoward UniversityUSA

Personalised recommendations