New Animal Model for Atherosclerosis Research

  • Charles E. Day
  • Walter W. Stafford
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 63)


Japanese quail were investigated for their utility as a model for the discovery and evaluation of anti-atherosclerosis compounds. Although they possessed suitable characteristics for a screening animal, their development of atherosclerosis was too variable to make them a practical model. A search was conducted to find a means to make quail uniformly atherosclerotic. To this end a line of quail susceptible to experimental atherosclerosis (SEA) were selectively bred. Thus, the SEA Japanese quail is a new animal model for atherosclerosis research.


CHOLIC Acid Cholesterol Diet Japanese Quail Aortic Atherosclerosis Upjohn Company 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    A. D. Ojerio, G. J. Pucak, T. B. Clarkson and B. C. Bullock. Lab. Animal Sci. 22: 33–39, 1972.Google Scholar
  2. 2.
    R. C. Bayer, R. K. Ringer and E. A. Cogger. Poultry Sci. 51: 925–929, 1972.CrossRefGoogle Scholar
  3. 3.
    R. L. Smith and D. M. Hilker. Atherosclerosis 17: 63–70, 1973.PubMedCrossRefGoogle Scholar
  4. 4.
    D. M. Tennent, H. Siegel, G. W. Kuron, W. H. Ott, and C. W. Mushett. Proc. Soc. Exptl. Biol. Med. 96: 679–683, 1957.Google Scholar
  5. 5.
    W. D. Block, K. J. Jarrett, and J. B. Levine. In: Automation in Analytical Chemistry, ed. by L. T. Skeggs, Mediad Incorporated, New York, 1966, pp. 345–347.Google Scholar
  6. 6.
    D. M. Kramsch, C. Franzblau and W. Hollander. J. Clin. Invest. 50: 1666–1677, 1971.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • Charles E. Day
    • 1
  • Walter W. Stafford
    • 1
  1. 1.Diabetes and Atherosclerosis ResearchThe Upjohn CompanyKalamazooUSA

Personalised recommendations