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The Heritable Hyperlipoproteinemias and Atherosclerosis

  • Chapter
Book cover Lipids, Lipoproteins, and Drugs

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 63))

Abstract

Hyperlipidemia can be caused by occasional or constant environmental factors, by genetic factors, by other primary diseases, or by various combinations (11–14, 16, 17, 28, 36, 37, 46, 48, 54, 57). Probably less than 10% of individuals from free living populations whose plasma cholesterol and triglyceride concentrations are a-voe the upper 95th percentile are carriers of genes for familial hyperlipoproteinemia (6, 46). A large numerical majority of individuals with hyperlipidemia have acquired the disorder primarily through diet, excessive alcohol intake, drugs, or other primary disease states (most frequently diabetes, hypothyroidism, nephrotic syndrome, liver disease). Hypercholesterolemia and hypertriglyceridemia acquired secondary to dietary habits are highly sensitive to minor changes in habitual life style. For the most part, the familial hyperlipoproteinemias require major changes in dietary habits and often the conjunction of diet and drug therapy is required to normalize blood lipids.

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Author information

Authors and Affiliations

  1. College of Medicine, Lipoprotein Research Laboratory and General Clinical Research Center, University of Cincinnati, Cincinnati, Ohio, USA

    Charles J. Glueck M. D.

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  1. Charles J. Glueck M. D.
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  2. Ronald W. Fallat M. D.
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Editors and Affiliations

  1. The Wistar Institute, Philadelphia, Pennsylvania, USA

    David Kritchevsky

  2. Institute of Pharmacology and Pharmacognosy, University of Milan, Milan, Italy

    Rodolfo Paoletti

  3. Division of Research, The Lankenau Hospital, Philadelphia, Pennsylvania, USA

    William L. Holmes

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© 1975 Plenum Press, New York

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Glueck, C.J., Fallat, R.W. (1975). The Heritable Hyperlipoproteinemias and Atherosclerosis. In: Kritchevsky, D., Paoletti, R., Holmes, W.L. (eds) Lipids, Lipoproteins, and Drugs. Advances in Experimental Medicine and Biology, vol 63. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3258-9_21

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  • DOI: https://doi.org/10.1007/978-1-4684-3258-9_21

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3260-2

  • Online ISBN: 978-1-4684-3258-9

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