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The Heritable Hyperlipoproteinemias and Atherosclerosis

  • Charles J. Glueck
  • Ronald W. Fallat
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 63)

Abstract

Hyperlipidemia can be caused by occasional or constant environmental factors, by genetic factors, by other primary diseases, or by various combinations (11–14, 16, 17, 28, 36, 37, 46, 48, 54, 57). Probably less than 10% of individuals from free living populations whose plasma cholesterol and triglyceride concentrations are a-voe the upper 95th percentile are carriers of genes for familial hyperlipoproteinemia (6, 46). A large numerical majority of individuals with hyperlipidemia have acquired the disorder primarily through diet, excessive alcohol intake, drugs, or other primary disease states (most frequently diabetes, hypothyroidism, nephrotic syndrome, liver disease). Hypercholesterolemia and hypertriglyceridemia acquired secondary to dietary habits are highly sensitive to minor changes in habitual life style. For the most part, the familial hyperlipoproteinemias require major changes in dietary habits and often the conjunction of diet and drug therapy is required to normalize blood lipids.

Keywords

Familial Hypercholesterolemia Combine Hyperlipidemia Autosomal Dominant Trait Free Living Population Familial Type 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • Charles J. Glueck
    • 1
  • Ronald W. Fallat
  1. 1.College of Medicine, Lipoprotein Research Laboratory and General Clinical Research CenterUniversity of CincinnatiCincinnatiUSA

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