The Heritable Hyperlipoproteinemias and Atherosclerosis

  • Charles J. Glueck
  • Ronald W. Fallat
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 63)


Hyperlipidemia can be caused by occasional or constant environmental factors, by genetic factors, by other primary diseases, or by various combinations (11–14, 16, 17, 28, 36, 37, 46, 48, 54, 57). Probably less than 10% of individuals from free living populations whose plasma cholesterol and triglyceride concentrations are a-voe the upper 95th percentile are carriers of genes for familial hyperlipoproteinemia (6, 46). A large numerical majority of individuals with hyperlipidemia have acquired the disorder primarily through diet, excessive alcohol intake, drugs, or other primary disease states (most frequently diabetes, hypothyroidism, nephrotic syndrome, liver disease). Hypercholesterolemia and hypertriglyceridemia acquired secondary to dietary habits are highly sensitive to minor changes in habitual life style. For the most part, the familial hyperlipoproteinemias require major changes in dietary habits and often the conjunction of diet and drug therapy is required to normalize blood lipids.


Familial Hypercholesterolemia Combine Hyperlipidemia Autosomal Dominant Trait Free Living Population Familial Type 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Adlersberg, D., Parets, A.D., and Boas, E. P.: J. A. M. A. 141: 246, 1949CrossRefGoogle Scholar
  2. 2.
    Andersen, G. E., and Clausen, J.: Z. Ernaehrungswiss 11: 120, 1972CrossRefGoogle Scholar
  3. 3.
    Bassen, F. A., and Kornzweig, A. L.: Blood 5: 381, 1950PubMedGoogle Scholar
  4. 4.
    Brown, M. S., Dana, S. E,, and Goldstein, J. L.: J. Biol. Chem. 249: 789, 1974aGoogle Scholar
  5. 5.
    Brown, M.S. and Goldstein, J. L.: Science 185: 61, 1974bCrossRefGoogle Scholar
  6. 6.
    Carlson, L. A., and Bottiger, L. E.: Lancet 1: 865, 1972PubMedCrossRefGoogle Scholar
  7. 7.
    Carter, C.O., Slack, J., Myant, N.B.: Lancet 1:400, 1971PubMedCrossRefGoogle Scholar
  8. 8.
    Cottrill, C., Glueck, C. J., Leuba, V., Millett, F., Puppione, D., and Brown, W. V.: Metabolism 23: 779, 1974PubMedCrossRefGoogle Scholar
  9. 9.
    Darmady, J. M., Fosbrooke, A. S., and Lloyd, J. K.: British Medical Journal 2: 685, 1972PubMedCrossRefGoogle Scholar
  10. 10.
    Fredrickson, D.S.: J. Clin. Investigation 43: 228, 1964CrossRefGoogle Scholar
  11. 11.
    Fredrickson, D.S., Lees, R. S., and Levy, R. I.: In Progress in Biochemical Pharmacology. Vol. 2, edited by R. Paoletti, D. Kritchevsky and D. Steinberg. Basel, Karger, p. 343, 1966.Google Scholar
  12. 12.
    Fredrickson, D.S., Levy, R. I., Lees, R. S.: New Eng. J. Med. 276: 32–44, 94–103, 148–156, 215–224, 273–281 (Jan. 5, 12, 19,26 and Feb. 2), 1967Google Scholar
  13. 13.
    Fredrickson, D.S.: Proc. Nat. Acad. Sci. U.S.A. 1138:46, Nov., 1969Google Scholar
  14. 14.
    Fredrickson, D.S.: British Med. J. 2:187, 1971CrossRefGoogle Scholar
  15. 15.
    Fredrickson, D. S., Gotto, A. M., and Levy, R. I.: In the Metabolic Basis of Inherited Disease, edited by Stanbury, J. B., Wyngaarden, J. B., and Fredrickson, D. S. McGraw-Hill,Google Scholar
  16. N. Y., 3rd ed., 1972, pp. 499–513.Google Scholar
  17. 16.
    Fredrickson, D.S. and Levy, R.I.:In Metabolic Basis of Inherited Disease, edited by Stanbury, J. D., Wyngaarden, J. B., and Fredrickson, D.S. McGraw-Hill, N. Y., 3rd ed., 1972, pp. 545–614Google Scholar
  18. 17.
    Fredrickson, D.S. and Breslow, J. L.: Ann. Rev. Med. 24: 315, 1973PubMedCrossRefGoogle Scholar
  19. 18.
    Glueck, C. J., Heckman, F., Schonfeld, M., Steiner, P., and Pearce, W.: Met. 20: 597, 1971Google Scholar
  20. 19.
    Glueck, C. J., Fallat, R., Buncher, R., Tsang, R., and Steiner, P.: Met. 22: 1403, 1973aGoogle Scholar
  21. 20.
    Glueck, C. J., Tsang, R., Fallat, R., Buncher, C. R., Evans, G., and Steiner, P.: Met. 22:1287, 1973bGoogle Scholar
  22. 21.
    Glueck, C. J., Fallat, R., Tsang, R., and Buncher, C. R.: Amer. J. Dis. Child. 127: 70, 1974aGoogle Scholar
  23. 22.
    Glueck, C. J., Fallat, R. W., and Tsang, R. C.: Amer. J. Dis. Child., in press, 1974bGoogle Scholar
  24. 23.
    Goldstein, J. L., Schrott, H. R., Hazzard, W. R., Bierman, E. L., Motulsky, A. G.: J. Clin. Invest. 52: 1544, 1973aPubMedCrossRefGoogle Scholar
  25. 24.
    Goldstein, J. L., Albers, J. J., Hazzard, W. R., Schott, H. R., Bierman, E. L., and Motulsky, A. G.: J. Clin. Invest. 52: abstract 127, p. 35A, 1973bGoogle Scholar
  26. 25.
    Goldstein, J. L. and Brown, M. S.: Proc. Nat. Acad. Sei.: 70: 2804, 1973cCrossRefGoogle Scholar
  27. 26.
    Gotto, A. M., Levy, R. I., John, K., and Fredrickson, D. S.: N. E. J. M. 284: 813, 1971CrossRefGoogle Scholar
  28. 27.
    Greten, H., Wengeler, H., and Wagner, H.: Nutr. Metabol. 15: 128, 1973CrossRefGoogle Scholar
  29. 28.
    Harlan, W. R., Jr., Graham, J. B., and Estes, E. H.: Medicine 45: 77, 1966CrossRefGoogle Scholar
  30. 29.
    Heinle, R. A., Levy, R. I., Fredrickson, D. S., and Gorlin, R.: Amer. J. Cardiol. 24: 178, 1969PubMedCrossRefGoogle Scholar
  31. 30.
    Isselbacher, K. H., Scheig, R., Plotkin, G. R. and Caulfield, J. B.: Medicine 43: 347, 1964PubMedGoogle Scholar
  32. 31.
    Jensen, J., Blankenhorn, D. H., and Konerup, V.: Circulation 36: 77, 1967PubMedGoogle Scholar
  33. 32.
    Jensen, J., and Blankenhorn, D. H.: The Am. J. Med. 52: 499, 1972CrossRefGoogle Scholar
  34. 33.
    Kannel, W. B., Castelli, W. P., Gordon, T. and McNamara, P. A.: Annals of Internal Medicine 74: 1, 1971PubMedGoogle Scholar
  35. 34.
    Khachadurian, A. K.: Am. J. Med. 37:402, 1964PubMedCrossRefGoogle Scholar
  36. 35.
    Kwiterovich, P. O., Levy, R. I. and Fredrickson, D. S.: Lancet 1: 118, 1973PubMedCrossRefGoogle Scholar
  37. 36.
    Lees, R. S., Wilson, D. E., Schonfeld, G., and Fleet, S.: Prog, in Med. Genetics 9: 237, 1973Google Scholar
  38. 37.
    Kwiterovich, P. O., Jr., Fredrickson, D. S., and Levy, R. I.: J. Clin. Invest. 53: 1237, 1974PubMedCrossRefGoogle Scholar
  39. 38.
    Levy, R. I., Langer, T., Gotto, A. M., and Fredrickson, D. S.: Clin. Res. 18: 539, 1970Google Scholar
  40. 39.
    Levy, R.I. and Rifkind, B. M.: Amer. J. Cardiol. 31:547, 1973PubMedCrossRefGoogle Scholar
  41. 40.
    Lewis, B. and Myant, N. B.: Clinical Science 32: 201, 1967PubMedGoogle Scholar
  42. 41.
    Loeper, J., Rouffy, J., Loeper, J.: Arch. Mal. Coeur. 12: Suppl. 1: 3–15, 1970–71PubMedGoogle Scholar
  43. 42.
    Lloyd, J. K. and Wolff, O. H.:In, Endocrine and Genetic Diseases of Childhood. Edited by L. I. Gardner. W. B. Saunders, Philadelphia, 1969, p. 937.Google Scholar
  44. 43.
    Mars, H., Lewis, L. A., Robertson, A. L., Jr., Butkus, A., and Williams, G. H., Jr.: Am. J. Med. 46:886, 1969PubMedCrossRefGoogle Scholar
  45. 44.
    Miettinen, T. A., Penttila, I. M., and Lampainen, E.: Clinical Genetics 3: 271, 1972PubMedCrossRefGoogle Scholar
  46. 45.
    Nevin, N. C. and Slack, J.: Journal of Medical Genetics 5: 9, 1968PubMedCrossRefGoogle Scholar
  47. 46.
    Nikkila, E. A., and Aro, A.: Lancet 1: 954, 1973PubMedCrossRefGoogle Scholar
  48. 47.
    Richet, G., Durepaire, H., Hartmann, L., Ollier, M. P., Polonovaki, J., and Maitrot, B.: Presse Med. 77: 2045, 1969PubMedGoogle Scholar
  49. 48.
    Rifkind, B. M.: trang Clinics in Endocrinology and Metabolism, Volume 2, B. M. Rifkind, editor. W. B. Saunders, Philadelphia, 1973, pp. 1–151.Google Scholar
  50. 49.
    Roberts, W. C., Levy, R. I. and Fredrickson, D. S.: Arch. Pathol. 90: 45, 1970Google Scholar
  51. 50.
    Rose, H. G., Kranz, P., Weinstock, M., Guliano, J., and Haft, J. I.: Am. J. Med. 54:148, 1973PubMedCrossRefGoogle Scholar
  52. 51.
    Salt, H. B., Wolff, O. H., Lloyd, J. K., Fosbrooke, A. S., Cameron, A. H., and Hubble, D. V.: Lancet 2: 325, I960Google Scholar
  53. 52.
    Schaefer, L. E., Adlersberg, D., and Steinberg, A. G.: Circulation 17: 537, 1958PubMedGoogle Scholar
  54. 53.
    Schreibman, P. H., Wilson, D. E., and Arky, -R. A.: New Eng. J. Med. 281: 981, 1969PubMedCrossRefGoogle Scholar
  55. 54.
    Schrott, H. G., Goldstein, J. L., Hazzard, W. R., McGoodwin, M. C. and Motulsky, A. G.: Annals of Int. Med. 76:711, 1972Google Scholar
  56. 55.
    Schwartz, J. F., Rowland, L. P., Eder, H., Marks, P.A., Osserman, E. F., Hirschberg, E., and Anderson, H.: Arch. Neurol. 8: 438, 1963CrossRefGoogle Scholar
  57. 56.
    Segal, M. M., Fosbrooke, A. S., Lloyd, J. K., and Wolf O. H.: Arch. Dis. Child. 45: 73, 1970CrossRefGoogle Scholar
  58. 57.
    Stone, N. J., Levy, R. I., Fredrickson, D. S., and Verter, J.: Circulation, supplement IV, XLVIII, 11–14, 1973Google Scholar
  59. 58.
    Slack, J. and Nevin, N. C.: J. Med. Genet. 5:4, 1968PubMedCrossRefGoogle Scholar
  60. 59.
    Slack, J.: Lancet 2: 1380, 1969PubMedCrossRefGoogle Scholar
  61. 60.
    Tamir, I,, Bojamower, Y., Levtow, O., Heldenberg, D., Dickerman, Z., and Werbin, B.: Archives of Disease in Childhood 47: 808, 1972PubMedCrossRefGoogle Scholar
  62. 61.
    Tsang, R. and Glueck, C. J. Amer. J. Dis. Children 127: 78, 1974Google Scholar
  63. 62.
    Tsang, R., Fallat, R. W., and Glueck, C. J.: Pediatrics 53: 458, 1974PubMedGoogle Scholar
  64. 63.
    Van Buchem, F. S. P., Pol, G., de Gier, J., Böttcher, C. J. F., and Pries, C.: Amer. J. Med. 40: 794, 1966PubMedCrossRefGoogle Scholar
  65. 64.
    Wolff, O. H.: Proc. Roy. Soc. Med. 60:1147, 1967PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • Charles J. Glueck
    • 1
  • Ronald W. Fallat
  1. 1.College of Medicine, Lipoprotein Research Laboratory and General Clinical Research CenterUniversity of CincinnatiCincinnatiUSA

Personalised recommendations