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The Role of Lipids in the Tissue Factor Pathway of Blood Coagulation

  • Yale Nemerson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 63)

Abstract

When blood is shed from a vein, collected into a glass tube and allowed to clot spontaneously, fibrin will form in about 15 or 20 minutes. On the other hand if small amounts of various tissues but particularly lung, brain, and placenta are added to this blood, it will clot in something of the order of 12 to 20 seconds. The fact that blood clots at all when withdrawn from the body is due to the initiation of a complex series of reactions involving many proteins, calcium ions and phospholipids. When no tissue extracts are added and the blood is allowed to simply clot spontaneously the initial reaction involves the activation of Factor XII or Hageman factor and the entire series of events which then follows is referred to as the intrinsic system. When tissue factor is added in the form of acetone powders of whole tissues or as a more purified preparation, the initiating event is the formation of a complex between tissue factor and a plasma protein Factor VII. The reactions which then lead to the formation of fibrin are called the extrinsic system or the tissue factor pathway of blood coagulation.

Keywords

Blood Coagulation Tissue Factor Phosphatidyl Ethanolamine Active Lipid Centrifugal Field 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • Yale Nemerson
    • 1
  1. 1.Department of Internal MedicineYale University-School of MedicineNew HavenUSA

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