The Role of Lipids in the Tissue Factor Pathway of Blood Coagulation

  • Yale Nemerson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 63)


When blood is shed from a vein, collected into a glass tube and allowed to clot spontaneously, fibrin will form in about 15 or 20 minutes. On the other hand if small amounts of various tissues but particularly lung, brain, and placenta are added to this blood, it will clot in something of the order of 12 to 20 seconds. The fact that blood clots at all when withdrawn from the body is due to the initiation of a complex series of reactions involving many proteins, calcium ions and phospholipids. When no tissue extracts are added and the blood is allowed to simply clot spontaneously the initial reaction involves the activation of Factor XII or Hageman factor and the entire series of events which then follows is referred to as the intrinsic system. When tissue factor is added in the form of acetone powders of whole tissues or as a more purified preparation, the initiating event is the formation of a complex between tissue factor and a plasma protein Factor VII. The reactions which then lead to the formation of fibrin are called the extrinsic system or the tissue factor pathway of blood coagulation.


Blood Coagulation Tissue Factor Phosphatidyl Ethanolamine Active Lipid Centrifugal Field 
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  1. 1.
    Ratnoff, O. D., and Rosenblum, J. M. J. Lab. Clin. Med. 50: 941, 1957Google Scholar
  2. 2.
    Cochrane, C.G. and Weupper, K. D. J. Exp. Med. 134:986, 1971PubMedCrossRefGoogle Scholar
  3. 3.
    Ratnoff, O. D. and Davie, E. W. Biochemistry 1: 967, 1962PubMedCrossRefGoogle Scholar
  4. 4.
    Fujikawa, K., Thompson, A. R., Legaz, M. E., Meyer, R. G. and Davie, E. W. Biochemistry 12: 4938, 1973PubMedCrossRefGoogle Scholar
  5. 5.
    Macfarlane, R. G., Biggs, R., Ash, B. J., and Denson, K. W. E. Brit. J. Haematol. 10: 530, 1964CrossRefGoogle Scholar
  6. 6.
    Hoagle, L., Denson, K. W. E. and Biggs, R. Thromb. Diath. Hoemuruh. 18: 211, 1967Google Scholar
  7. 7.
    Nemerson, Y. Biochemistry 5: 601, 1966PubMedCrossRefGoogle Scholar
  8. 8.
    Radcliffe, R. and Barton, P. G. J. Biol. Chem. 248: 6788, 1973PubMedGoogle Scholar
  9. 9.
    Hemker, H. C., Esnouf, M. P., Hemker, P. W., Swart, A. C. W. and Macfarlane, R. G. Nature 215: 248, 1967PubMedCrossRefGoogle Scholar
  10. 10.
    Bettelheim, F. R. and Baily, K. Biochem. Biophys. Acta 9: 578, 1952PubMedCrossRefGoogle Scholar
  11. 11.
    Lorand, L., Konishi, K. and Jacobsen, A. Nature 194: 1148, 1962PubMedCrossRefGoogle Scholar
  12. 12.
    Nemerson, Y. and Esnouf, M. P. Proc. Nat. Acad. Sci. (USA) 70: 310, 1973CrossRefGoogle Scholar
  13. 13.
    Studer, A. 1946. In: Jubilee Volume dedicated to Emile Christophe Barell. The Roche Companies, Basel.Google Scholar
  14. 14.
    Kuhn, R. and Klesse, P. C. Naturwissenschaften 44: 352, 1957CrossRefGoogle Scholar
  15. 15.
    Deutsch, E., Irsigler, K. and Lomoschitz, H. Thromb. Diath. Haemorrh 12: 12, 1964PubMedGoogle Scholar
  16. 16.
    Nemerson, Y. J. Clin. Invest. 47: 72, 1968PubMedCrossRefGoogle Scholar
  17. 17.
    Huatum, M. and Prydz, H. Thromb. Diath. Haemorrh 21: 217, 1969Google Scholar
  18. 18.
    Nemerson, Y. J. Clin. Invest. 47:72, 1968; 48:322, 1969.CrossRefGoogle Scholar
  19. 19.
    Pitlick, F. A. and Nemerson, Y. Biochemistry 9: 5105, 1970PubMedCrossRefGoogle Scholar
  20. 20.
    Gammack, D. B., Perrin, J. H. and Saunders, L. Biochim. Biophys. Acta 84: 576, 1964PubMedGoogle Scholar
  21. 21.
    Perrin, J. H. and Saunders, L. Biochim. Biophys. Acta 84: 216, 1964PubMedGoogle Scholar
  22. 22.
    Fleischer, S., Klouwen, H. and Carpenter, E. Biochem. Biophys. Res. Commun. 5: 378, 1961CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • Yale Nemerson
    • 1
  1. 1.Department of Internal MedicineYale University-School of MedicineNew HavenUSA

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