Experimental and Clinical Evaluation of Two “Atromid-S” Analogues in Relation to their Differential Modes of Action

  • M. C. Stone
  • J. M. Thorp
  • J. S. Wain
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 63)

Abstract

There is increasing evidence that plasma fibrinogen and some of its partial breakdown products may play a critical role in the initiation of atherosclerosis, the rheology of blood, and the availability of oxygen to the vessel wall and tissues. Pilgeram and Pickart (1) suggested that the hepatic synthesis of fibrinogen is related to the concentration of non-esterified fatty acids (FFA) in plasma. It is recognized that acute tissue damage (surgery, myocardial infarction) is followed by an increase of FFA and (later) of fibrinogen, with a sharp reduction of cholesterol-rich low-density lipoproteins (LDL).

Keywords

Cholesterol Toxicity Glycerol Albumin Carbohydrate 

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Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • M. C. Stone
    • 1
  • J. M. Thorp
    • 2
  • J. S. Wain
    • 2
  1. 1.Research Unit, Leigh Infirmary, Leigh, LancashireImperial Chemical Industries Ltd.Macclesfield, CheshireUK
  2. 2.Research DepartmentImperial Chemical Industries Ltd.Macclesfield, CheshireUK

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