Experimental and Clinical Evaluation of Two “Atromid-S” Analogues in Relation to their Differential Modes of Action
There is increasing evidence that plasma fibrinogen and some of its partial breakdown products may play a critical role in the initiation of atherosclerosis, the rheology of blood, and the availability of oxygen to the vessel wall and tissues. Pilgeram and Pickart (1) suggested that the hepatic synthesis of fibrinogen is related to the concentration of non-esterified fatty acids (FFA) in plasma. It is recognized that acute tissue damage (surgery, myocardial infarction) is followed by an increase of FFA and (later) of fibrinogen, with a sharp reduction of cholesterol-rich low-density lipoproteins (LDL).
KeywordsCholesterol Toxicity Glycerol Albumin Carbohydrate
Unable to display preview. Download preview PDF.
- 2.Barrett, A.M. and Thorp, J. M. Br. J. Pharm. Chem. 32: 381, 1968.Google Scholar
- 4.Thorp, J. M. and Barrett, A.M. Prog. Biochem. Pharmacol. 2: 337, 1967.Google Scholar
- 5.Barrett, A. M. Br. J. Pharm. Chem. 26: 363, 1966.Google Scholar
- 6.Thorp, J. M. In: Atherosclerosis: Proceedings of the Second International Symposium (R. J. Jones, editor), p. 541, 1970.Google Scholar
- 8.Thorp, J. M. Excerpta Medica Int. Congr. Series 254: 98, 1971.Google Scholar
- 9.Thorp, J. M. Excerpta Medica Int. Congr. Series 283: 90, 1973.Google Scholar
- 11.Benaim, M. E., Dewar, H. A. and Thorp, J. M. In preparation.Google Scholar
- 14.Hart, A., Thorp, J. M. and Cohen, H. Postgrad. Med. J. 48: 435, 1971.Google Scholar
- 15.Hart, A., Cohen, H. and Thorp, J. M. Unpublished observations.Google Scholar
- 17.Bottiger, L. E. and Carlson, L. A. In: Early Phases of Coronary Heart Disease-Skandia Symposia 1972. J. Waldstrom, T. Larsson, and N. Ljungstadt, editors, p. 158.Google Scholar