Nuclear Transplantation and the Analysis of Gene Activity in Early Amphibian Development

  • J. B. Gurdon
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 241)


Amphibian eggs are large and tolerant to the injection of small pipettes. For this reason they are particularly well suited for microinjection experiments. This paper discusses certain types of injection experiments that have proved informative in the analysis of gene activity in development.


Nuclear Transfer Skin Cell Nuclear Transplantation Adult Frog Cleavage Cell 


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  1. Arms, K. (1968). J. Embryol exp. Morph. 20, 367.Google Scholar
  2. Bonner, W. M. 1975 ). J. Cell Biol 64, 421.CrossRefGoogle Scholar
  3. Ecker, R. E., Smith, L. D. (1971). DeveL Biol 24, 559.CrossRefGoogle Scholar
  4. Elsdale, T. R., Fischberg, M., Smith, S. (1958). Exptl Cell Res. 14, 642.CrossRefGoogle Scholar
  5. Elsdale, T. R., Gurdon, J. B., Fischberg, M. (1960). J. Embryol exp. Morph. 8, 437.Google Scholar
  6. Gurdon, J. B. (1962). J. Embryol exp. Morph. 10, 622.Google Scholar
  7. Gurdon, J. B. (1970). Proc. R. Soc. B. 176, 303.CrossRefGoogle Scholar
  8. Gurdon, J. B. (1974a). The Control of Gene Expression in Animal Development (Harvard Press), p. 160.Google Scholar
  9. Gurdon, J. B. (1974b). Nature 248, 772.CrossRefGoogle Scholar
  10. Gurdon, J. B., Laskey, R.A. (1970a). J. Embryol exp. Morph. 24, 227.Google Scholar
  11. Gurdon, J. B., Laskey, R.A. (1970b). J. Embryol exp. Morph. 24, 249.Google Scholar
  12. Gurdon, J. B., Woodland, H.R., Lingrel, J.B. (1974). DeveL Biol 39, 125.CrossRefGoogle Scholar
  13. Gurdon, J. B., Laskey, R. A., Reeves, O.R. (1975). J. Embryol exp. Morph. 34. (In press.)Google Scholar
  14. Laskey, R. A., Gurdon, J. B. (1970). Nature 228, 1332.Google Scholar
  15. Merriam, R. W. (1969). J. Cell Sci 5, 333.Google Scholar
  16. Reeves, O. R. (1975). J. Embryol exp. Morph. 34. (Inpress.)Google Scholar
  17. Reeves, O. R., Laskey, R. A. (1975). J. Embryol exp. Morph. 34. (In press.)Google Scholar
  18. Wallace, H. R., Birnstiel, M. L. (1966). Biochimr Biophys. Acta. 114, 296.Google Scholar
  19. Woodland, H. R., Gurdon, J. B., Lingrel, J. B. (1974). DeveL Biol 39, 134.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • J. B. Gurdon
    • 1
  1. 1.M.R.C. LaboratoryCambridgeEngland

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