Preformed mRNA and the Programming of Early Embryo Development

  • Abraham Marcus
  • Sara Spiegel
  • John D. Brooker
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 241)


Growth and development of an organism can be characterized as the implementation of a series of sequentially operative genetic programs. The process includes first a determination of the particular program, i.e. selectivity at the level of genomic transcription, and then either an immediate proceeding into its application, i.e. translation, or alternatively, holding the program in abeyance awaiting an activation reaction. In two systems, both of which involve early embryonic development, there appears to be substantial evidence that the latter of these two alternatives, namely the activation of a previously transcribed program, does indeed serve as a significant control. The systems are the fertilization of echinoderm and amphibian eggs, and the germination of seed embryos.


Isocitric Lyase Early Embryo Development Seed Embryo Wheat Embryo Template Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Aviv, H., Leder, P. (1972). Proc. Natl Acad. Sci 69, 1408.CrossRefGoogle Scholar
  2. Bell, E., Reeder, R. (1967). Biochim. Biophys. Acta 142, 500.Google Scholar
  3. Brambl, R. M., Van Etten, J. L. (1970). Archives Biochem. and Biophys. 137, 442.CrossRefGoogle Scholar
  4. Ceccarini, C., Maggio, R., Barbata, G. (1967). Proc. Natl Acad. Sci. 58, 2235.Google Scholar
  5. Crawford, R. B., Wilde jr., C. E., Heineman, M. H., Hendler, F. J. (1973). J. Embryol. Exp. Morph. 29, 363.Google Scholar
  6. Davidson, E. H., Crippa, M., Kramer, F. R., Mirsky, A. E. (1966). Proc. Natl. Acad Sci 56, 856.CrossRefGoogle Scholar
  7. Davidson, E. H., Hough, B. R. (1971). J. Mol. Biol. 56, 491.CrossRefGoogle Scholar
  8. Denny, P. C., Tyler, A. (1964). Biochem. Biophys. Res. Comm. 14, 245.CrossRefGoogle Scholar
  9. Ecker, R. E., Smith, L. D., Subtelny, S. (1968). Science 160, 1115.Google Scholar
  10. Edmonds, M., Vaughn, M.H., Nakazato, H. (1971). Proc. Natl. Acad. Sci 68, 1336.Google Scholar
  11. Epel, D. (1967). Proc. Natl. Acad. Sci 57, 889.Google Scholar
  12. Gambino, R, Metafora, S., Felicetti, L., Raisman, J. (1973). Biochim. Biophys. Acta 312, 377.Google Scholar
  13. Gross, K. W., Jacobs-Lorena, M., Baglioni, C., Gross, P. R. (1973). Proc. Natl Acad. Sci 70, 2614.Google Scholar
  14. Gross, P. R., Malkin, L. I., Moyer, W. A. (1964). Proc. Natl. Acad. Sci. 51, 407.CrossRefGoogle Scholar
  15. Hultin, T. (1961). Exptl Cell Res. 25, 405.CrossRefGoogle Scholar
  16. Hultin, T. (1964). Develop. Biol. 10, 305.CrossRefGoogle Scholar
  17. Humphreys, T. (1969). Develop. Biol. 20, 435.CrossRefGoogle Scholar
  18. Bile, J. N., Dure, L. S. (1972a). J. Biol Chem. 247, 5034.Google Scholar
  19. Ihle, J. N., Dure, L. S. (1972b). J. Biol Chem. 247, 5048.Google Scholar
  20. Jenkins, N., Taylor, M. W., Raff, R. A. (1973). Proc. Natl. Acad. Sci 70, 3287.CrossRefGoogle Scholar
  21. Kedes, L. H., Birnsteil, M. L. (1971). Nature N. B. 230, 165.Google Scholar
  22. Lee, S. Y., Mendeck, J., Brawerman, G. (1971). Proc. Natl Acad. Sci 68, 1331.Google Scholar
  23. Linskens, H. F. (1969). Planta 85, 175.CrossRefGoogle Scholar
  24. MacKintosh, F. R., Bell, E. (1969). Exp. Cell Res. 57, 71.CrossRefGoogle Scholar
  25. Mano, Y. (1966). Biochem. Biophys. Res. Comm. 25, 216.CrossRefGoogle Scholar
  26. Mano, Y., Nagano, H. (1966). Biochem. Biophys. Res. Comm. 25, 210.CrossRefGoogle Scholar
  27. Marcus, A. (1969). Symp. Soc. Exp. Biol. 23, 143.Google Scholar
  28. Marcus, A., Feeley, J. (1964). Proc. Natl Acad Sci 51, 1075.Google Scholar
  29. Marcus, A., Feeley, J. (1965). J. Biol Chem. 240, 1675.Google Scholar
  30. Marcus, A., Feeley, J. (1966). Proc. Natl Acad. Sci. 56, 1770.Google Scholar
  31. Marcus A., Feeley, J.,Volcani, T. (1966). Plant Physiol 41, 1167.CrossRefGoogle Scholar
  32. Mascarenhas, J. P., Bell, E. (1969). Biochim. Biophys. Acta 179, 199.Google Scholar
  33. Mescher, A., Humphreys, T. (1974). Nature 249, 138.CrossRefGoogle Scholar
  34. Metafora, S., Felicetti, L., Gambino, R. (1971). Proc. Natl Acad. Sci. 68, 600.CrossRefGoogle Scholar
  35. Monroy, A., Maggio, R., Rinaldi, A. M. (1965). Proc. Natl Acad. Sci. 54, 107.CrossRefGoogle Scholar
  36. Monroy, A., Tyler, A. (1963). Arch. Biochem. Biophys. 103, 431.CrossRefGoogle Scholar
  37. Nakana, E., Monroy, A. (1958). Exptl. Cell Res. 14, 236.CrossRefGoogle Scholar
  38. Obendorf, R. L., Marcus, A. (1974). Pl. Physiol 53, 779.CrossRefGoogle Scholar
  39. Pollock, B. M., Toole, V. K. (1966). Plant Physiol 41, 221.CrossRefGoogle Scholar
  40. Raff, R. A., Colot, H. V., Selvig, A. E., Gross, P. R. (1972). Nature 235, 211.CrossRefGoogle Scholar
  41. Raff, R. A., Greenhouse, G. A., Gross, K., Gross, P. R. (1971). J. Cell Biol 50, 516.CrossRefGoogle Scholar
  42. Rinaldi, A. M., Monroy, A. (1969). Develop. Biol 19, 73.CrossRefGoogle Scholar
  43. Rosbash, M., Ford, P. J. (1974). J. Mol. Biol 85, 87.CrossRefGoogle Scholar
  44. Ruderman, J. V., Bagiioni, C., Gross, P. R. (1974). Nature 247, 36.CrossRefGoogle Scholar
  45. Ruderman, J. V., Gross, P. R. (1974). Develop. Biol 36, 286.CrossRefGoogle Scholar
  46. Schultz, G. A., Chen, D., Katchalski, E. (1972). J. Mol Biol 66, 379.CrossRefGoogle Scholar
  47. Sheldon, R., Jurale, C., Kates, J. (1972). Proc. Natl Acad. Sci. 69, 417.CrossRefGoogle Scholar
  48. Skoultchi, A., Gross, P.R. (1973). Proc. Natl Acad. Sci. 70, 2840.CrossRefGoogle Scholar
  49. Slater, D. W., Slater, I., Gillespie, D. (1972). Nature 240, 333.CrossRefGoogle Scholar
  50. Slater, D. W., Spiegelman, S. (1966). Proc. Natl Acad. Sci. 56, 164.CrossRefGoogle Scholar
  51. Slater, L, Gillespie, D., Slater, D. W. (1973). Proc. Natl Acad. Sci 70, 406.CrossRefGoogle Scholar
  52. Slater, L, Slater, D. W. (1974). Proc. Natl Acad. Sci 71, 1103.Google Scholar
  53. Smith, L. D., Ecker, R. E., Subtelny, S. (1966). Proc. Natl Acad Sci 56, 1724.Google Scholar
  54. Spirin, A. S. (1966). Curr. Topics in Develop. Biol 1, 1.CrossRefGoogle Scholar
  55. Stafford, D. W., Sofer, W. H., Iverson, R. M. (1964). Proc. Natl. Acad Sci. 52, 313.CrossRefGoogle Scholar
  56. Stavy, L., Gross, P. R. (1967). Proc. Natl Acad. Sci. 57, 735.CrossRefGoogle Scholar
  57. Terman, S. A. (1970). Proc. Natl Acad. Sci. 65, 985.CrossRefGoogle Scholar
  58. Van Etten, J. L., Roker, H. R., Davies, E. (1972). J. Bact. 112, 1029.Google Scholar
  59. Weeks, D. P., Marcus, A. (1971). Biochim. Biophys. Acta 232, 671.Google Scholar
  60. Whiteley, A. H., McCarthy, B. J., Whiteley, H. R. (1966). Proc. Natl Acad Sci 55, 519.CrossRefGoogle Scholar
  61. Wilt, F.H. (1973). Proc. Natl Acad Sci 70, 2345.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • Abraham Marcus
    • 1
  • Sara Spiegel
    • 1
  • John D. Brooker
    • 1
  1. 1.Fox Chase Center for Cancer and Medical SciencesThe Institute for Cancer ResearchPhiladelphiaUSA

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