Technique of Total Parenteral Nutrition in Infants
Normal growth and development in any animal species nourished entirely by vein was achieved for the first time in Beagle puppies in the Harrison Department of Surgical Research of the University of Pennsylvania in 1965 (Dudrick et al., 1967; Dudrick et al., 1970), Repeated demonstrations of normal growth and development in subsequent litters of puppies as well as positive nitrogen balance in adult surgical patients suggested the feasibility and safety of providing all nutrients entirely by vein to newborn human infants. Based on knowledge of the daily average oral pediatric nutritional requirements, on information obtained from the puppy studies, and on serial serum and urine measurements during infusions of dextrose, nitrogen, vitamins, minerals and electrolytes in man, a solution providing theoretically adequate intravenous requirements of the major nutrients for newborn infants was developed (Wilmore et al., 1968; Dudrick et al., 1969; Wilmore et al.,). Initially, 4 gm of protein in the form of fibrin hydrolysate were given per kilogram body weight daily. Subsequently, normal growth and development have been achieved in infants receiving 2½ to 3 gm of intravenous protein hydrolysates/kg/day.
KeywordsTotal Parenteral Nutrition External Jugular Vein Exit Site Intravenous Lipid Emulsion Invert Sugar
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