Technique of Total Parenteral Nutrition in Infants

  • Stanley J. Dudrick
  • Bruce V. MacFadyen
  • Robert W. Winters
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 46)


Normal growth and development in any animal species nourished entirely by vein was achieved for the first time in Beagle puppies in the Harrison Department of Surgical Research of the University of Pennsylvania in 1965 (Dudrick et al., 1967; Dudrick et al., 1970), Repeated demonstrations of normal growth and development in subsequent litters of puppies as well as positive nitrogen balance in adult surgical patients suggested the feasibility and safety of providing all nutrients entirely by vein to newborn human infants. Based on knowledge of the daily average oral pediatric nutritional requirements, on information obtained from the puppy studies, and on serial serum and urine measurements during infusions of dextrose, nitrogen, vitamins, minerals and electrolytes in man, a solution providing theoretically adequate intravenous requirements of the major nutrients for newborn infants was developed (Wilmore et al., 1968; Dudrick et al., 1969; Wilmore et al.,). Initially, 4 gm of protein in the form of fibrin hydrolysate were given per kilogram body weight daily. Subsequently, normal growth and development have been achieved in infants receiving 2½ to 3 gm of intravenous protein hydrolysates/kg/day.


Total Parenteral Nutrition External Jugular Vein Exit Site Intravenous Lipid Emulsion Invert Sugar 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Asch, M.J., Huxtable, R.F. and Hays, D.M. Arch. Surg., 104, 434, 1972.CrossRefGoogle Scholar
  2. Ashcraft, K.W. and Leape, L. J.A.M.A., 212, 454, 1970.CrossRefGoogle Scholar
  3. Bernard, R.W., Stahl, W.H. and Chase, R.M. Ann. Surg., 173, 191, 1971.CrossRefGoogle Scholar
  4. Borresen, H.C., Coran, A.G. and Knutrud, O. Ann. Surg., 172, 291, 1970.CrossRefGoogle Scholar
  5. Caldwell, M.D., Jonsson, H.T. and Otherson, H.B. J. Ped., 81, 894, 1972.CrossRefGoogle Scholar
  6. Curry, C.R. and Quie, P.G. N. Engl. J. Med., 285, 1221, 1971.CrossRefGoogle Scholar
  7. Das, J.B., Filler, R.M., Rubin, V.G. and Eraklis, A.J. J. Ped. Surg., 5, 127, 1970.CrossRefGoogle Scholar
  8. Dudrick, S.J., Rhoads, J.E. and Vars, H.M. in Fortschritte der Parenteralen Ernahrung. Symposium of the International Society of Parenteral Nutrition in 1966. Pallas Verlag, Lochham bei Munchen, West Germany, 1967.Google Scholar
  9. Dudrick, S.J., Steiger, E., Wilmore, D.W. and Vars, H.M. Lab. Anim. Care, 20, 521, 1970.Google Scholar
  10. Dudrick, S.J. and Wilmore, D.W. Hosp. Prac, 3, 65, 1968.Google Scholar
  11. Dudrick, S.J., Wilmore, D.W., Vars, H.M. and Rhoads, J.E. Ann. Surg., 169, 974, 1969.CrossRefGoogle Scholar
  12. Flint, J.M. Bull. Hopkins Hosp., 23, 127, 1912.Google Scholar
  13. Ruberg, R.L., Allen, T.R., Goodman, M.J., Long, J.M. and Dudrick, S.J. Surg Forum, 22, 86, 1971.Google Scholar
  14. Wilmore, D.W. and Dudrick, S.J. J.A.M.A., 203, 860, 1968.CrossRefGoogle Scholar
  15. Wilmore, D.W., Dudrick, S.J., Daly, J.M. and Vars, H.M. Surg., Gynecol., Obstet., 132, 673, 1971.Google Scholar
  16. Wilmore, D.W., Groff, D.B., Bishop, H.C. and Dudrick, S.J. J. Ped. Surg., 4, 181, 1969.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1974

Authors and Affiliations

  • Stanley J. Dudrick
    • 1
  • Bruce V. MacFadyen
    • 1
  • Robert W. Winters
    • 1
  1. 1.The Program in Surgery, Texas Medical CenterThe University of Texas Medical School at HoustonHoustonUSA

Personalised recommendations