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Initiation of Transcription by RNA Polymerases of E. Coli and Phage T3

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Control of Gene Expression

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 44))

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Abstract

Unlike eukaryotes, bacteria possess only a single species of RNA polymerase which is responsible for the expression of the entire genetic information of the cell. Evidence for a single enzyme comes from the action of the drug rifampicin, which interacts with RNA polymerase and upon addition to a cell culture eliminates the synthesis of ribosomal, transfer and messenger RNA. A single-step mutation of rifampicin resistance restores the ability to synthesize all RNA species in the presence of the drug (1).

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© 1974 Plenum Press, New York

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Bautz, E.K.F., McAllister, W.T., Küpper, H., Beck, E., Bautz, F.A. (1974). Initiation of Transcription by RNA Polymerases of E. Coli and Phage T3. In: Kohn, A., Shatkay, A. (eds) Control of Gene Expression. Advances in Experimental Medicine and Biology, vol 44. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3246-6_2

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  • DOI: https://doi.org/10.1007/978-1-4684-3246-6_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3248-0

  • Online ISBN: 978-1-4684-3246-6

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