Initiation of Transcription by RNA Polymerases of E. Coli and Phage T3

  • E. K. F. Bautz
  • W. T. McAllister
  • H. Küpper
  • E. Beck
  • F. A. Bautz
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 44)


Unlike eukaryotes, bacteria possess only a single species of RNA polymerase which is responsible for the expression of the entire genetic information of the cell. Evidence for a single enzyme comes from the action of the drug rifampicin, which interacts with RNA polymerase and upon addition to a cell culture eliminates the synthesis of ribosomal, transfer and messenger RNA. A single-step mutation of rifampicin resistance restores the ability to synthesize all RNA species in the presence of the drug (1).


Phosphodiester Bond Nucleoside Triphosphate Promotor Site Core Enzyme Allosteric Effector 
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Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • E. K. F. Bautz
    • 1
  • W. T. McAllister
    • 1
  • H. Küpper
    • 1
  • E. Beck
    • 1
  • F. A. Bautz
    • 1
  1. 1.Institut für Molekulare Genetik Universität Heidelberg69 HeidelbergWest Germany

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