Initiation of Transcription by RNA Polymerases of E. Coli and Phage T3
Unlike eukaryotes, bacteria possess only a single species of RNA polymerase which is responsible for the expression of the entire genetic information of the cell. Evidence for a single enzyme comes from the action of the drug rifampicin, which interacts with RNA polymerase and upon addition to a cell culture eliminates the synthesis of ribosomal, transfer and messenger RNA. A single-step mutation of rifampicin resistance restores the ability to synthesize all RNA species in the presence of the drug (1).
KeywordsPhosphodiester Bond Nucleoside Triphosphate Promotor Site Core Enzyme Allosteric Effector
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- 1.YURA, T., IGARASHI, K. El MASUKATA, K. (1970). In Lepetit Colloquium on RNA Polymerase and Transcription (Silvestri, ed.) p. 71, North Holland Publ.Co., Amsterdam.Google Scholar
- 8.GOLDTHWAIT, D.A., ANTHONY, D.D. E1 WU, C-W (1970). In Lepetit Colloquium on RNA Polymerase and Transcription (Silvestri, ed) p. 10, North Holland Publ.Co., Amsterdam.Google Scholar