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Studies on the Replicase of Encephalomyocarditis Virus

  • B. Diskin
  • H. Rosenberg
  • A. Traub
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 44)

Abstract

The RNA-dependent RNA polymerases (replicases) of the small RNA animal viruses which belong to the picornavirus group (polio, mengo, encephalomyocarditìs, etc.) were discovered about ten years ago (1). They were found in the cytoplasm of infected cells, bound to relatively large structures, sedimentìng between 200 to 300 S. The enzyme is associated with a double-stranded RNA template — a duplex made of a parental viral RNA strand and its complementary strand. It is the complementary (-) strand of the duplex which serves as template for the transcription of molecules of progeny viral RNA which are then incorporated into virions.

Keywords

Gradient Fraction Micrococcal Nuclease Core Enzyme Encephalomyocarditis Virus Smooth Membrane 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • B. Diskin
    • 1
  • H. Rosenberg
    • 1
  • A. Traub
    • 1
  1. 1.Biochemistry DepartmentIsrael Institute for Biological ResearchNess ZionaIsrael

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