Faulty Proteins: Altered Gene Products in Senescent Cells and Organisms

  • H. Gershon
  • P. Zeelon
  • D. Gershon
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 44)


The process of senescence is characterized by a progressive inability of the individual organism to defend itself against environmental insults. Superficially, the deterioration of the aging organism may appear to be composed of various degenerative processes occurring simultaneously. However, in attempting to formulate the simplest possible explanation for the many alterations observed in senescence, that is, to present a theory of aging, the initial causes of the modifications occurring at the subcellular level, whose effects are then expressed as the gross defects observed in the aging organism, should be considered.


Senescent Cell Enzyme Molecule C57Bl Mouse Heat Inactivation Double Diffusion 


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Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • H. Gershon
    • 1
  • P. Zeelon
    • 2
  • D. Gershon
    • 2
  1. 1.Department of ImmunologyAba Khoushy School of MedicineHaifaIsrael
  2. 2.Department of BiologyTechnion - Israel Institute of TechnologyHaifaIsrael

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